Figure 3

In vivo treatment of PSP and γ-T3. The in vivo therapeutic effect of PSP and γ-T3 was examined in a nude mouse model with PC3-GFP cells. Nude mice were randomized into four groups, each consisting of five animals. Each group was treated daily for 30 days with either γ-T3 (50 mg/Kg/day), PSP (300 mg/Kg/day), γ-T3 (50 mg/Kg/day) plus PSP (300 mg/Kg/day and or DMSO and PBS as the control group. (A) Tumor volume in each group was evaluated using Maestro imaging system. Representative mice in each group were shown. (B) γ-T3 administration reduced the tumor size by ~2 folds as compared with control and its effect was similar to PSP alone. The combination of γ-T3 and PSP exhibited a synergistic effect on tumor suppression (P < 0.01, t test).