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Table 2 Pharmacokinetic parameters obtained alter the oral administration of 100:25 mg/kg levodopa/carbidopa in the three groups studied (initial situation; treatment with Plantago ovata husk and treatment with placebo) to 18 Parkinson patients

From: A randomised clinical trial to evaluate the effects of Plantago ovata husk in Parkinson patients: changes in levodopa pharmacokinetics and biochemical parameters

  Initial situation Treatment A (Plantago ovata husk) Treatment B (Placebo)
Parameters Mean ± SD CV(%) Mean ± SD CV(%) Mean ± SD CV(%)
t max (min) 35.83 ± 16.91 47.20 39.72 ± 17.19 43.28 36.17 ± 26.30 59.56
C max (ng/ml) 603.2 ± 242.4 40.19 547.8 ± 192.6 35.16 612.0 ± 176.6 28.86
AUC (μg.min/ml) 62.87 ± 15.77 25.09 64.47 ± 15.27 23.69 65.10 ± 14.33 22.01
λ (min -1 ) 0.0096 ± 0.0018 18.87 0.0088 ± 0.0020 22.54 0.0097 ± 0.0018 18.40
V ss /F (l) 0.1845 ± 0.0628 34.05 0.1929 ± 0.0521 27.04 0.1699 ± 0.0468 27.58
Cl/F (l/min) 0.0017 ± 0.0004 25.98 0.0016 ± 0.0004 23.89 0.0016 ± 0.0004 22.52
AUMC (μg.min 2 /ml) 7881.7 ± 2630.3 33.37 8313.7 ± 2284.4 27.48 8327.1 ± 2651.9 31.85
MRT (min) 125.1 ± 29.9 23.93 129.2 ± 21.7 16.78 126.6 ± 24.2 19.13
C min (ng/ml) 6.02 ± 3.41 56.70 6.31 ± 7.10 112.58 7.34 ± 7.98 108.71
t 1/2λ (min) 75.2 ± 16.0 21.27 81.9 ± 15.3 18.70 74.0 ± 16.9 22.86