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Table 3 Cytotoxicity and antioxidant effect of TTHL isolated product from ethnolic extract of C. leprosum in S. cerevisiae

From: The natural triterpene 3β,6β,16β-trihydroxy-lup-20(29)-ene obtained from the flowers of Combretum leprosum induces apoptosis in MCF-7 breast cancer cells

Yeast strains

Treatment

WT

sod1 Δ

sod2 Δ

sod1 Δsod2 Δ

NCa

100.0 ± 0.0

100.0 ± 0.0

100.0 ± 0.0

100.0 ± 0.0

TTHL 10 μg/mL

100 ± 2.83

92.60 ± 2.83

83.20 ± 3.68**

79.35 ± 2.19**

TTHL 50 μg/mL

87.65 ± 5.16**

89.30 ± 0.85**

72.90 ± 7.07***

67.85 ± 10.54***

TTHL 100 μg/mL

79.45 ± 1.91***

75.65 ± 4.60***

62.25 ± 3.32***

58.15 ± 3.89***

TTHL 500 μg/mL

67.65 ± 3.04***

69.30 ± 3.68***

56.65 ± 1.06***

41.45 ± 4.03***

PCb: H2O2 5 mM

63.03 ± 4.12

16.27 ± 4.88

19.10 ± 4.03

19.33 ± 2.10

  1. aNC: negative control (solvent-DMSO). Data significant in relation to negative control group (solvent) at *P < 0.05, **P < 0.01 and ***P < 0.001/ one-way ANOVA Tukey’s multiple comparison test. bPositive control (H2O2).
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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