Figure 8
From: Artemisia annua L.: evidence of sesquiterpene lactones’ fraction antinociceptive activity
Evidences of the involvement of opioid system in the antinociception caused by Lac-FR. The antinociceptive effect increase of morphine (5 mg/kg i.p.), morphine (5 mg/kg i.p.) associated with naloxone (5 mg/kg s.c.), and Lac-FR (100 mg/kg i.p.) associated with naloxone (5 mg/kg s.c.), after one hour period were 70.21% (morphine), 21.94% (morphine with naloxone), 16.62% (Lac-FR with naloxone), and 46.96% (Lac-FR 100 mg/kg i.p.), respectively. Evaluation times were 0.5, 1, 2, 4, and 24 hs. (ANOVA and Bonferroni’s test. ***p < 0.001, **p < 0.01, *p < 0.05).