Evaluation of the potential anti-inflammatory effects of Lac-FR. Effect of the Lac-FR on carrageenan-induced paw edema expressed as paw edema (mL) per time after inflammation induction. Mice were pretreated i.p. with Lac-FR (100 and 300 mg/kg), and vehicle (10 ml/kg i.p.), 30 min before the intraplantar 2.5% carrageenan injection. Paw edema was evaluated in plethysmometer 2, 4, 6, and 24 hours after inflammation induction. (ANOVA and Bonferroni’s test. ***p < 0.001, **p < 0.01; *p < 0.05).