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Table 1 Safety evaluation of W-LHIT treatment

From: Weight loss herbal intervention therapy (W-LHIT) a non-appetite suppressing natural product controls weight and lowers cholesterol and glucose levels in a murine model

Treatment Dose Time Death (12 hrs) Death (24 hrs) Morbidity percentage Mortality percentage
Acute Water 10X 1 day 0/5 0/5 0 0
W-LHIT 10X 1 day 0/5 0/5 0 0
Chronic Water 5X 14 days 0/5 0/5 0 0
W-LHIT 5X 14 days 0/5 0/5 0 0
  BUN (mg/dL) Alanine aminotransferase (U/L) White blood cells (10^3/ μL) Red blood cells (10^6/ μL) Hemoglobin (g/dL) Platelets (10^3/ μL) neutrophils (10^3/ μL) lymphocytes (10^3/ μL) eosinophils (10^3/ μL) Basophils (10^3/ μL)
Water 27.0 ± 2.8 27.5 ± 10.6 6.6 ± 3.1 6.6 ± 3.5 13.7 ± 1.0 1155.0 ± 706.8 2920.5 ± 1247.2 3340.0 ± 2248.2 63.8 ± 82.1 0.0 ± 0.0
W-LHIT 21.0 ± 4.4 33.0 ± 5.4 6.0 ± 3.5 8.1 ± 0.6 12.9 ± 0.8 1056.2 ± 526.3 2233.4 ± 1692.3 3499.2 ± 1763.0 52.0 ± 71.3 0.0 ± 0.0
Reference 14-32 16-58 5.4-16.0 6.7-9.71 10.2-16.6 799-1300 1900-3600 8000-18000 0-500 0-400
  1. No morbidity or mortality was observed in acute and chronic W-LHIT treated or normal control mice. Liver and kidney function test and complete blood test results were all in normal range.
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