Figure 1

Enhancement of tamoxifen-induced cytotoxicity in breast cancer cell lines by SCS. Percentage of cell death following treatment with DMSO (control); SCS (8.5 and 10.0 μg/ml for MCF-7 and MDA-MB-231 cells, respectively); 2.5, 5.0, 10.0 and 15.0 μM tamoxifen (T2.5-T15); and their combination with SCS (C2.5-C15) was determined at 6, 12, 24 and 48 h using the LDH assay. Data shown are the mean values ± SD from three independent experiments. Statistical analyses was determined using one-way ANOVA followed by post hoc Tukey multiple comparison test with *p < 0.05, **p < 0.01, ***p < 0.001, significantly different from control; ^ap < 0.05, ^bp < 0.01, ^cp < 0.001, combination treatment compared to tamoxifen.