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Table 2 Pharmacokinetic parameters of furosemide (10 mg/kg) after co-administration of DA-9801 at a single oral dose of 1,000 mg/kg

From: Evaluation of the transporter-mediated herb-drug interaction potential of DA-9801, a standardized dioscorea extract for diabetic neuropathy, in human in vitro and rat in vivo

  5 min pre-dose of DA-9801 (n = 5) 2 h pre-dose of DA-9801 (n = 5)
  Control DA-9801 Control DA-9801
Tmax (h) 0.600 ± 0.518 1.35 ± 0.602 0.250 ± 0.000 0.550 ± 0.411
Cmax (μg/mL) 1.32 ± 0.330 0.896 ± 0.212 1.92 ± 0.619 1.98 ± 0.364
t1/2 (h) 3.40 ± 1.51 3.95 ± 1.09 3.40 ± 1.43 3.06 ± 0.920
AUC8h (μg/mL · h) 4.00 ± 1.02 4.94 ± 2.58 4.67 ± 0.819 5.96 ± 1.11
AUC (μg/mL · h) 4.91 ± 1.29 5.61 ± 1.09 5.59 ± 0.528 7.37 ± 1.08
CL/F (mL/min/kg) 36.7 ± 13.5 30.5 ± 5.46 30.0 ± 2.73 23.0 ± 3.72
Amount excreted in urine (% of dose) 20.2 ± 7.19 30.4 ± 14.7 17.5 ± 6.87 25.7 ± 5.70