Table 2 Pharmacokinetic parameters of furosemide (10 mg/kg) after co-administration of DA-9801 at a single oral dose of 1,000 mg/kg

T_max (h)

0.600 ± 0.518

1.35 ± 0.602

0.250 ± 0.000

0.550 ± 0.411

C_max (μg/mL)

1.32 ± 0.330

0.896 ± 0.212

1.92 ± 0.619

1.98 ± 0.364

t_1/2 (h)

3.40 ± 1.51

3.95 ± 1.09

3.40 ± 1.43

3.06 ± 0.920

AUC_8h (μg/mL · h)

4.00 ± 1.02

4.94 ± 2.58

4.67 ± 0.819

5.96 ± 1.11

AUC_∞ (μg/mL · h)

4.91 ± 1.29

5.61 ± 1.09

5.59 ± 0.528

7.37 ± 1.08

CL/F (mL/min/kg)

36.7 ± 13.5

30.5 ± 5.46

30.0 ± 2.73

23.0 ± 3.72

Amount excreted in urine (% of dose)

20.2 ± 7.19

30.4 ± 14.7

17.5 ± 6.87

25.7 ± 5.70