Skip to main content

Table 1 Pharmacokinetic parameters of cimetidine (10 mg/kg) after co-administration of DA-9801 at a single oral dose of 1,000 mg/kg

From: Evaluation of the transporter-mediated herb-drug interaction potential of DA-9801, a standardized dioscorea extract for diabetic neuropathy, in human in vitro and rat in vivo

 

5 min pre-dose of DA-9801 (n = 5)

2 h pre-dose of DA-9801 (n = 5)

 

Control

DA-9801

Control

DA-9801

Tmax (h)

0.700 ± 0.326

2.50 ± 0.707**

0.300 ± 0.112

1.20 ± 1.24

Cmax (ng/mL)

652 ± 120

337 ± 100**

995 ± 305

532 ± 175*

t1/2 (h)

1.12 ± 0.130

1.45 ± 0.620

1.09 ± 0.139

1.20 ± 0.125

AUC8h (μg/mL · h)

1.77 ± 0.314

1.34 ± 0.154

1.80 ± 0.372

1.78 ± 0.290

AUC∞ (μg/mL · h)

1.79 ± 0.313

1.41 ± 0.122

1.82 ± 0.382

1.82 ± 0.304

CL/F (mL/min/kg)

95.2 ± 15.7

119 ± 9.56

94.1 ± 15.5

93.5 ± 13.8

Amount excreted in urine (% of dose)

23.2 ± 4.53

16.3 ± 10.9

24.1 ± 11.2

27.4 ± 3.23

  1. *p < 0.05, for the comparison with the control group.
  2. **p <0.01, for the comparison with control group.