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Table 1 Pharmacokinetic parameters of cimetidine (10 mg/kg) after co-administration of DA-9801 at a single oral dose of 1,000 mg/kg

From: Evaluation of the transporter-mediated herb-drug interaction potential of DA-9801, a standardized dioscorea extract for diabetic neuropathy, in human in vitro and rat in vivo

  5 min pre-dose of DA-9801 (n = 5) 2 h pre-dose of DA-9801 (n = 5)
  Control DA-9801 Control DA-9801
Tmax (h) 0.700 ± 0.326 2.50 ± 0.707** 0.300 ± 0.112 1.20 ± 1.24
Cmax (ng/mL) 652 ± 120 337 ± 100** 995 ± 305 532 ± 175*
t1/2 (h) 1.12 ± 0.130 1.45 ± 0.620 1.09 ± 0.139 1.20 ± 0.125
AUC8h (μg/mL · h) 1.77 ± 0.314 1.34 ± 0.154 1.80 ± 0.372 1.78 ± 0.290
AUC (μg/mL · h) 1.79 ± 0.313 1.41 ± 0.122 1.82 ± 0.382 1.82 ± 0.304
CL/F (mL/min/kg) 95.2 ± 15.7 119 ± 9.56 94.1 ± 15.5 93.5 ± 13.8
Amount excreted in urine (% of dose) 23.2 ± 4.53 16.3 ± 10.9 24.1 ± 11.2 27.4 ± 3.23
  1. *p < 0.05, for the comparison with the control group.
  2. **p <0.01, for the comparison with control group.