| 5 min pre-dose of DA-9801 (n = 5) | 2 h pre-dose of DA-9801 (n = 5) | ||
---|---|---|---|---|
 | Control | DA-9801 | Control | DA-9801 |
Tmax (h) | 0.700 ± 0.326 | 2.50 ± 0.707** | 0.300 ± 0.112 | 1.20 ± 1.24 |
Cmax (ng/mL) | 652 ± 120 | 337 ± 100** | 995 ± 305 | 532 ± 175* |
t1/2 (h) | 1.12 ± 0.130 | 1.45 ± 0.620 | 1.09 ± 0.139 | 1.20 ± 0.125 |
AUC8h (μg/mL · h) | 1.77 ± 0.314 | 1.34 ± 0.154 | 1.80 ± 0.372 | 1.78 ± 0.290 |
AUC∞ (μg/mL · h) | 1.79 ± 0.313 | 1.41 ± 0.122 | 1.82 ± 0.382 | 1.82 ± 0.304 |
CL/F (mL/min/kg) | 95.2 ± 15.7 | 119 ± 9.56 | 94.1 ± 15.5 | 93.5 ± 13.8 |
Amount excreted in urine (% of dose) | 23.2 ± 4.53 | 16.3 ± 10.9 | 24.1 ± 11.2 | 27.4 ± 3.23 |