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Figure 1 | BMC Complementary and Alternative Medicine

Figure 1

From: Evaluation of the transporter-mediated herb-drug interaction potential of DA-9801, a standardized dioscorea extract for diabetic neuropathy, in human in vitro and rat in vivo

Figure 1

Inhibitory effect of DA-9801 on the transport activities of OCT1 (A), OCT2 (B), OAT1 (C), OAT3 (D), OATP1B1 (E), OATP1B3 (F), P-gp (G), and BCRP (H). Inhibitory effect of DA-9801 (1–300 μg/ml) on the uptake of 0.1 μM [3H]methyl-4-phenylpyridinium (MPP+; a substrate for OCT1 and OCT2), 1 μM [14C]para- aminohippuric acid (PAH; a substrate for OAT1), 0.1 μM [3H]estrone-3-sulfate (ES; a substrate for OAT3, OATP1B1, and BCRP), 0.1 μM [3H]estradiol-17β-D-glucuronide (EG; a substrate for OATP1B3), and 0.1 μM [3H]digoxin (a substrate for P-gp) were measured. Data point represents the mean ± SD of three independent experiments. Data were fitted to an inhibitory effect Emax model and the IC50 value was calculated.

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