Antifungal and cytotoxicity activities of the fresh xylem sap of Hymenaea courbaril L. and its major constituent fisetin

Table 1 In vitro antifungal activity of the sap and fisetin of H. courbaril

Isolates	Minimum inhibitory concentration (μg/mL)
Isolates	Fresh xylem sap				Fisetin
	Range	MIC₅₀	MIC₉₀	GM	Range	MIC₅₀	MIC₉₀	GM
Dermatophytes (n)
M. gypseum (2)	64-128	128	128	90.5	64-128	128	128	90.5
T. mentagrophytes (8)	32-128	64	128	83	32-128	64	128	69.8
T. rubrum (7)	32-128	64	128	64	4-64	32	64	21.5
T. tonsurans (1)	128	128	128	128	128	128	128	128
Yeasts (n)
C. gattii (4)	128-256	128	256	181	128	128	128	128
C. neoformans (22)	8-256	64	256	68,2	8-128	64	128	48.2

MIC₅₀ - inhibit the growth of 50% of isolates;
MIC₉₀ - Minimal inhibitory concentration to inhibit the growth of 90% of isolates;
GM = Geometric Mean.

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