Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on streptozotocin induced diabetic rats

Table 8 Effect of methanol/dichloromethane extract of Albizzia Lebbeck Benth. . stem bark (ALEx) on renal function parameters in normal & STZ induced diabetic treated rats

Groups	Renal function parameters
Groups	Blood urea nitrogen (BUN) (mM/L)	Glycated serum protein (GSP) (μ mol/L)	Serum creatinine (μ mol/L)
Normal rats (untreated with dimethylsulfoxide, [DMSO]) Group 1	6.54 ± 0.1503	152.3 ± 0.5651	27.35 ± 0.1943
Diabetic control (administered with Streptozotocin (STZ) Group 2	13.63 ± 0.1404	313.9 ± 1.426	37.29 ± 0.1431
Diabetic control + (ALEx) (100 mg/kg body weight) Group 3	12.11 ± 0.02990^ns	285.7 ± 1.548^ns	34.54 ± 0.1297
Diabetic control + (ALEx) (200 mg/kg body weight) Group 4	10.53 ± 0.1070	204.1 ± 1.795	33.43 ± 0.1779^ns
Diabetic control + (ALEx) (300 mg/kg body weight) Group 5	8.48 ± 0.1101**	181.9 ± 0.3565*	32.29 ± 0.1512**
Diabetic control + (ALEx) (400 mg/kg body weight) Group 6	7.586 ± 0.1244***	162.2 ± 0.6422***	30.24 ± 0.06719***
Diabetic control + Glibenclamide (1 mg/kg b wt.) Group 7	7.122 ± 0.03121***	160.8 ± 0.3589***	29.5 ± 0.1336

The data are expressed as mean ± SEM. (n = number of animals in each group = 5). The comparisons were made by one way ANOVA followed by Dunnent’s test.
ns = non-significant, STZ = Streptozotocin.
*p < 0.05 is considered as significant when compared to the control group (0 h).
**p < 0.001 is considered as very significant when compared to the control group (0 h).
***p < 0.001 is considered as extremely significant when compared to the control group (0 h).

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