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Table 8 Effect of methanol/dichloromethane extract of Albizzia Lebbeck Benth. . stem bark (ALEx) on renal function parameters in normal & STZ induced diabetic treated rats

From: Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on streptozotocin induced diabetic rats

Groups Renal function parameters
Blood urea nitrogen (BUN) (mM/L) Glycated serum protein (GSP) (μ mol/L) Serum creatinine (μ mol/L)
Normal rats (untreated with dimethylsulfoxide, [DMSO]) Group 1 6.54 ± 0.1503 152.3 ± 0.5651 27.35 ± 0.1943
Diabetic control (administered with Streptozotocin (STZ) Group 2 13.63 ± 0.1404 313.9 ± 1.426 37.29 ± 0.1431
Diabetic control + (ALEx) (100 mg/kg body weight) Group 3 12.11 ± 0.02990ns 285.7 ± 1.548ns 34.54 ± 0.1297
Diabetic control + (ALEx) (200 mg/kg body weight) Group 4 10.53 ± 0.1070 204.1 ± 1.795 33.43 ± 0.1779ns
Diabetic control + (ALEx) (300 mg/kg body weight) Group 5 8.48 ± 0.1101** 181.9 ± 0.3565* 32.29 ± 0.1512**
Diabetic control + (ALEx) (400 mg/kg body weight) Group 6 7.586 ± 0.1244*** 162.2 ± 0.6422*** 30.24 ± 0.06719***
Diabetic control + Glibenclamide (1 mg/kg b wt.) Group 7 7.122 ± 0.03121*** 160.8 ± 0.3589*** 29.5 ± 0.1336
  1. The data are expressed as mean ± SEM. (n = number of animals in each group = 5). The comparisons were made by one way ANOVA followed by Dunnent’s test.
  2. ns = non-significant, STZ = Streptozotocin.
  3. *p < 0.05 is considered as significant when compared to the control group (0 h).
  4. **p < 0.001 is considered as very significant when compared to the control group (0 h).
  5. ***p < 0.001 is considered as extremely significant when compared to the control group (0 h).