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Table 7 Effect of methanol/dichloromethane extract ofAlbizzia Lebbeck Benth.. stem bark (ALEx) on oxidative stress parameters in normal & STZ induced diabetic treated rats

From: RETRACTED ARTICLE: Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on streptozotocin induced diabetic rats

Groups

Oxidative stress

SOD (units/mg protein)

CAT (μ mol/min/mg protein)

GSH-px (μ mol/min/mg protein)

GSH (mM/100 g tissue)

Normal rats (untreated with dimethylsulfoxide, [DMSO]) Group 1

10.3 ± 0.1642

86.24 ± 0.7028

12.51 ± 0.1523

56.23 ± 0.5273

Diabetic control (administered with Streptozotocin (STZ) Group 2

2.67 ± 0.07218

25.28 ± 0.4598

6.274 ± 0.1402

24.58 ± 0.1815

Diabetic control + (ALEx) (100 mg/kg body weight) Group 3

3.794 ± 0.1306

26.89 ± 0.3122ns

6.628 ± 0.08243

25.7 ± 0.1362

Diabetic control + (ALEx) (200 mg/kg body weight) Group 4

6.366 ± 0.01965

38.08 ± 0.4018

7.28 ± 0.01304ns

35.69 ± 0.2022

Diabetic control + (ALEx) (300 mg/kg body weight) Group 5

7.44 ± 0.1626**

58.61 ± 0.2086**

9.694 ± 0.1273

41.36 ± 0.5254**

Diabetic control + (ALEx) (400 mg/kg body weight) Group 6

9.474 ± 0.1209**

75.88 ± 0.6258***

11.64 ± 0.04104***

52.71 ± 0.4298***

Diabetic control + Glibenclamide (1 mg/kg b wt.) Group 7

10.41 ± 0.1322

84.3 ± 0.5113

12.53 ± 0.1955

54.52 ± 0.3057

  1. The data are expressed as mean ± SEM. (n = number of animals in each group = 5). The comparisons were made by one way ANOVA followed by Dunnent’s test.
  2. ns = non-significant, STZ = Streptozotocin.
  3. **p < 0.001 is considered as very significant when compared to the control group (0 h).
  4. ***p < 0.001 is considered as extremely significant when compared to the control group (0 h).