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Table 7 Effect of methanol/dichloromethane extract of Albizzia Lebbeck Benth. . stem bark (ALEx) on oxidative stress parameters in normal & STZ induced diabetic treated rats

From: Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on streptozotocin induced diabetic rats

Groups Oxidative stress
SOD (units/mg protein) CAT (μ mol/min/mg protein) GSH-px (μ mol/min/mg protein) GSH (mM/100 g tissue)
Normal rats (untreated with dimethylsulfoxide, [DMSO]) Group 1 10.3 ± 0.1642 86.24 ± 0.7028 12.51 ± 0.1523 56.23 ± 0.5273
Diabetic control (administered with Streptozotocin (STZ) Group 2 2.67 ± 0.07218 25.28 ± 0.4598 6.274 ± 0.1402 24.58 ± 0.1815
Diabetic control + (ALEx) (100 mg/kg body weight) Group 3 3.794 ± 0.1306 26.89 ± 0.3122ns 6.628 ± 0.08243 25.7 ± 0.1362
Diabetic control + (ALEx) (200 mg/kg body weight) Group 4 6.366 ± 0.01965 38.08 ± 0.4018 7.28 ± 0.01304ns 35.69 ± 0.2022
Diabetic control + (ALEx) (300 mg/kg body weight) Group 5 7.44 ± 0.1626** 58.61 ± 0.2086** 9.694 ± 0.1273 41.36 ± 0.5254**
Diabetic control + (ALEx) (400 mg/kg body weight) Group 6 9.474 ± 0.1209** 75.88 ± 0.6258*** 11.64 ± 0.04104*** 52.71 ± 0.4298***
Diabetic control + Glibenclamide (1 mg/kg b wt.) Group 7 10.41 ± 0.1322 84.3 ± 0.5113 12.53 ± 0.1955 54.52 ± 0.3057
  1. The data are expressed as mean ± SEM. (n = number of animals in each group = 5). The comparisons were made by one way ANOVA followed by Dunnent’s test.
  2. ns = non-significant, STZ = Streptozotocin.
  3. **p < 0.001 is considered as very significant when compared to the control group (0 h).
  4. ***p < 0.001 is considered as extremely significant when compared to the control group (0 h).