Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on streptozotocin induced diabetic rats

Table 6 Effect of methanol/dichloromethane extract of Albizzia Lebbeck Benth. . stem bark (ALEx) on lipid profile in normal & STZ induced diabetic treated rats

Groups	Serum lipid profile
Groups	Total cholesterol (TC) (mg/dL)	HDL cholesterol (HDL-c) (mg/dL)	LDL cholesterol (LDL-c)	Triglycerides (TG) (mg/dL)	Hepatic glycogen (mg glucose equivalents/mg wet tissue)
Normal rats (untreated with dimethylsulfoxide, [DMSO]) Group 1	128.9 ± 0.3926	53.19 ± 0.4878	27.18 ± 0.5619	77.57 ± 0.5943	49.7 ± 0.2316
Diabetic control (administered with Streptozotocin (STZ) Group 2	273 ± 0.7544	14.25 ± 0.2791	105.81 ± 0.8731^ns	193.1 ± 1.424	17.21 ± 0.09793
Diabetic control + (ALEx) (100 mg/kg body weight) Group 3	201.8 ± 0.3189^ns	15.26 ± 0.1843	82.56 ± 0.4372**	191.7 ± 0.4291	19.17 ± 0.1649
Diabetic control + (ALEx) (200 mg/kg body weight) Group 4	188.1 ± 0.4720	28.27 ± 0.5883	81.11 ± 1.201	161.6 ± 0.5797^ns	25.41 ± 0.4521
Diabetic control + (ALEx) (300 mg/kg body weight) Group 5	162.8 ± 0.3100**	34.69 ± 0.5712*	43.94 ± 0.6629	131.3 ± 0.4677	38.41 ± 0.2578*
Diabetic control + (ALEx) (400 mg/kg body weight) Group 6	141.4 ± 0.4808***	43.74 ± 0.3495***	30.09 ± 0.3958***	93.57 ± 1.389**	41.68 ± 0.3041***
Diabetic control + Glibenclamide (1 mg/kg b wt.) Group 7	145.7 ± 0.5246	48.02 ± 0.1643	28.51 ± 0.7293	81.99 ± 0.5388	48.05 ± 0.1163

The data are expressed as mean ± SEM. (n = number of animals in each group = 5). The comparisons were made by one way ANOVA followed by Dunnent’s test.
ns = non-significant, STZ = Streptozotocin.
*p < 0.05 is considered as significant when compared to the control group (0 h).
**p < 0.001 is considered as very significant when compared to the control group (0 h).
***p < 0.001 is considered as extremely significant when compared to the control group (0 h).

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