Skip to main content

Advertisement

Table 6 Effect of methanol/dichloromethane extract of Albizzia Lebbeck Benth. . stem bark (ALEx) on lipid profile in normal & STZ induced diabetic treated rats

From: Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on streptozotocin induced diabetic rats

Groups Serum lipid profile
Total cholesterol (TC) (mg/dL) HDL cholesterol (HDL-c) (mg/dL) LDL cholesterol (LDL-c) Triglycerides (TG) (mg/dL) Hepatic glycogen (mg glucose equivalents/mg wet tissue)
Normal rats (untreated with dimethylsulfoxide, [DMSO]) Group 1 128.9 ± 0.3926 53.19 ± 0.4878 27.18 ± 0.5619 77.57 ± 0.5943 49.7 ± 0.2316
Diabetic control (administered with Streptozotocin (STZ) Group 2 273 ± 0.7544 14.25 ± 0.2791 105.81 ± 0.8731ns 193.1 ± 1.424 17.21 ± 0.09793
Diabetic control + (ALEx) (100 mg/kg body weight) Group 3 201.8 ± 0.3189ns 15.26 ± 0.1843 82.56 ± 0.4372** 191.7 ± 0.4291 19.17 ± 0.1649
Diabetic control + (ALEx) (200 mg/kg body weight) Group 4 188.1 ± 0.4720 28.27 ± 0.5883 81.11 ± 1.201 161.6 ± 0.5797ns 25.41 ± 0.4521
Diabetic control + (ALEx) (300 mg/kg body weight) Group 5 162.8 ± 0.3100** 34.69 ± 0.5712* 43.94 ± 0.6629 131.3 ± 0.4677 38.41 ± 0.2578*
Diabetic control + (ALEx) (400 mg/kg body weight) Group 6 141.4 ± 0.4808*** 43.74 ± 0.3495*** 30.09 ± 0.3958*** 93.57 ± 1.389** 41.68 ± 0.3041***
Diabetic control + Glibenclamide (1 mg/kg b wt.) Group 7 145.7 ± 0.5246 48.02 ± 0.1643 28.51 ± 0.7293 81.99 ± 0.5388 48.05 ± 0.1163
  1. The data are expressed as mean ± SEM. (n = number of animals in each group = 5). The comparisons were made by one way ANOVA followed by Dunnent’s test.
  2. ns = non-significant, STZ = Streptozotocin.
  3. *p < 0.05 is considered as significant when compared to the control group (0 h).
  4. **p < 0.001 is considered as very significant when compared to the control group (0 h).
  5. ***p < 0.001 is considered as extremely significant when compared to the control group (0 h).