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Table 5 Effect of methanol/dichloromethane extract ofAlbizzia Lebbeck Benth.stem bark (ALEx) on hepatic enzymes in normal & STZ induced diabetic treated rats

From: RETRACTED ARTICLE: Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on streptozotocin induced diabetic rats

Groups

Biochemical Parameters of Hepatic enzymes

Hepatic hexokinase (units/min/mg of protein)

Gluocse-6-phosphatase (units/min/mg of protein)

Fructose 1-6-biphosphatase (units/min/mg of protein)

Glucose-6-phosphate dehydrogenase (units/min/mg of protein)

Normal rats (untreated with dimethylsulfoxide, [DMSO]) Group 1

0.214 ± 0.9152

0.176 ± 1.583

0.0282 ± 0.8437

0.128 ± 3.020

Diabetic control (administered with Streptozotocin (STZ) Group 2

0.112 ± 1.056

0.273 ± 0.6038

0.0596 ± 1.492

0.058 ± 4.576ns

Diabetic control + (ALEx) (100 mg/kg body weight) Group 3

0.13 ± 0.9104ns

0.241 ± 0.5943ns

0.0536 ± 0.6264ns

0.0614 ± 3.447

Diabetic control + (ALEx) (200 mg/kg body weight) Group 4

0.142 ± 0.2780

0.219 ± 0.3499**

0.0496 ± 0.4148

0.0622 ± 3.083

Diabetic control + (ALEx) (300 mg/kg body weight) Group 5

0.17 ± 0.5145

0.197 ± 1.831***

0.0386 ± 0.7895**

0.0892 ± 7.843

Diabetic control + (ALEx) (400 mg/kg body weight) Group 6

0.210 ± 0.8454***

0.181 ± 0.8955***

0.0298 ± 1.464

0.122 ± 3.408**

Diabetic control + Glibenclamide (1 mg/kg b wt.) Group 7

0.212 ± 0.7552

0.172 ± 0.4005

0.0287 ± 0.8724

0.127 ± 1.711***

  1. The data are expressed as mean ± SEM. (n = number of animals in each group = 5). The comparisons were made by one way ANOVA followed by Dunnent’s test.
  2. ns = non-significant, STZ = Streptozotocin.
  3. **p < 0.001 is considered as very significant when compared to the control group (0 h).
  4. ***p < 0.001 is considered as extremely significant when compared to the control group (0 h).