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Table 5 Effect of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on hepatic enzymes in normal & STZ induced diabetic treated rats

From: Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on streptozotocin induced diabetic rats

Groups Biochemical Parameters of Hepatic enzymes
Hepatic hexokinase (units/min/mg of protein) Gluocse-6-phosphatase (units/min/mg of protein) Fructose 1-6-biphosphatase (units/min/mg of protein) Glucose-6-phosphate dehydrogenase (units/min/mg of protein)
Normal rats (untreated with dimethylsulfoxide, [DMSO]) Group 1 0.214 ± 0.9152 0.176 ± 1.583 0.0282 ± 0.8437 0.128 ± 3.020
Diabetic control (administered with Streptozotocin (STZ) Group 2 0.112 ± 1.056 0.273 ± 0.6038 0.0596 ± 1.492 0.058 ± 4.576ns
Diabetic control + (ALEx) (100 mg/kg body weight) Group 3 0.13 ± 0.9104ns 0.241 ± 0.5943ns 0.0536 ± 0.6264ns 0.0614 ± 3.447
Diabetic control + (ALEx) (200 mg/kg body weight) Group 4 0.142 ± 0.2780 0.219 ± 0.3499** 0.0496 ± 0.4148 0.0622 ± 3.083
Diabetic control + (ALEx) (300 mg/kg body weight) Group 5 0.17 ± 0.5145 0.197 ± 1.831*** 0.0386 ± 0.7895** 0.0892 ± 7.843
Diabetic control + (ALEx) (400 mg/kg body weight) Group 6 0.210 ± 0.8454*** 0.181 ± 0.8955*** 0.0298 ± 1.464 0.122 ± 3.408**
Diabetic control + Glibenclamide (1 mg/kg b wt.) Group 7 0.212 ± 0.7552 0.172 ± 0.4005 0.0287 ± 0.8724 0.127 ± 1.711***
  1. The data are expressed as mean ± SEM. (n = number of animals in each group = 5). The comparisons were made by one way ANOVA followed by Dunnent’s test.
  2. ns = non-significant, STZ = Streptozotocin.
  3. **p < 0.001 is considered as very significant when compared to the control group (0 h).
  4. ***p < 0.001 is considered as extremely significant when compared to the control group (0 h).