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Table 3 Effect of methanol/dichloromethane extract ofAlbizzia Lebbeck Benth. stem bark (ALEx) during 120 min (2 h) on OGTT in normal & STZ induced diabetic treated rats

From: RETRACTED ARTICLE: Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on streptozotocin induced diabetic rats

Groups

Time (h)

0 h

0.5 h

1 h

1.5 h

2 h

Normal rats (untreated with dimethylsulfoxide, [DMSO]) Group 1

94.03 ± 1.193

135 ± 2.159

144.5 ± 1.385

155.9 ± 1.153

164.8 ± 1.785

Diabetic control (administered with Streptozotocin (STZ) Group 2

265.7 ± 1.070

275.9 ± 1.205ns

286.4 ± 1.180ns

296.6 ± 0.9096ns

306.8 ± 0.9778

Diabetic control + (ALEx) (100 mg/kg body weight) Group 3

255 ± 1.086

265 ± 0.8882ns

273.4 ± 1.024ns

283.1 ± 1.020ns

292 ± 0.8426ns

Diabetic control + (ALEx) (200 mg/kg body weight) Group 4

245.2 ± 0.9767

254.8 ± 0.8538

263 ± 1.724**

271.8 ± 1.421

280.4 ± 1.148**

Diabetic control + (ALEx) (300 mg/kg body weight) Group 5

234.2 ± 1.263

242.3 ± 1.136**

251.6 ± 0.8199**

261.7 ± 0.9516

270.8 ± 0.6865**

Diabetic control + (ALEx) (400 mg/kg body weight) Group 6

217.1 ± 1.329***

240.3 ± 0.4723**

250 ± 0.5276**

258 ± 0.7415

265.3 ± 0.6950***

Diabetic control + Glibenclamide (1 mg/kg b wt.) Group 7

221.9 ± 0.6154

242.2 ± 0.6026**

252.1 ± 0.7302***

261.1 ± 0.8815

269 ± 0.5970***

  1. The data are expressed as mean ± SEM. (n = number of animals in each group = 5). The comparisons were made by one way ANOVA followed by Dunnent’s test.
  2. ns = non-significant, STZ = Streptozotocin.
  3. **p < 0.001 is considered as very significant when compared to the control group (0 h).
  4. ***p < 0.001 is considered as extremely significant when compared to the control group (0 h).