Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on streptozotocin induced diabetic rats

Table 2 Effect of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on plasma insulin level in normal & STZ induced diabetic treated rats

Groups	Plasma Insulin level in μ at different time interval of experimentation
Groups	At start (On 1st day)	On 21st day	On 45th day
Normal rats (untreated with dimethylsulfoxide, [DMSO]) Group 1	18.22 ± 0.2077	17.17 ± 0.2059	16.39 ± 0.3864
Diabetic control (administered with Streptozotocin (STZ) Group 2	4.31 ± 0.1612	3.27 ± 0.1263^ns	2.29 ± 0.1619^ns
Diabetic control + (ALEx) (100 mg/kg body weight) Group 3	4.96 ± 0.09011	6.81 ± 0.03929^ns	6.78 ± 0.1546
Diabetic control + (ALEx) (200 mg/kg body weight) Group 4	5.03 ± 0.1771	6.46 ± 0.1928	7.49 ± 0.1608
Diabetic control + (ALEx) (300 mg/kg body weight) Group 5	6.68 ± 0.1338	7.59 ± 0.1604	8.29 ± 0.1517*
Diabetic control + (ALEx) (400 mg/kg body weight) Group 6	7.79 ± 0.04665*	13.07 ± 0.2095***	15.66 ± 0.1776***
Diabetic control + Glibenclamide (1 mg/kg b wt.) Group 7	7.89 ± 0.2871	13.81 ± 0.1706***	16.64 ± 0.1518***

The data are expressed as mean ± SEM. (n = number of animals in each group = 5). The comparisons were made by one way ANOVA followed by Dunnent’s test.
ns = non-significant, STZ = Streptozotocin.
*p < 0.05 is considered as significant when compared to the control group (0 h).
***p < 0.001 is considered as extremely significant when compared to the control group (0 h).

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