Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on streptozotocin induced diabetic rats

Table 1 Effect of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on blood glucose level in normal & STZ induced diabetic treated rats

Groups	Blood glucose level in mg/dL at different time interval of experimentation
Groups	At start (On 1st day)	On 21st day	On 45th day
Normal rats (untreated with dimethylsulfoxide, [DMSO]) Group 1	83.78 ± 1.031	86.45 ± 1.003	90.00 ± 0.4292
Diabetic control (administered with Streptozotocin (STZ) Group 2	305.4 ± 2.065	317.3 ± 1.612	372.3 ± 2.233
Diabetic control + (ALEx) (100 mg/kg body weight) Group 3	295.6 ± 1.842	250.1 ± 2.338^ns	208.9 ± 0.5738^ns
Diabetic control + (ALEx) (200 mg/kg body weight) Group 4	288 ± 0.4932	235.4 ± 0.8799^ns	155.7 ± 0.4750
Diabetic control + (ALEx) (300 mg/kg body weight) Group 5	283 ± 0.7396	200.2 ± 0.3971*	125.2 ± 1.196*
Diabetic control + (ALEx) (400 mg/kg body weight) Group 6	282 ± 0.6635**	166.1 ± 0.7504**	91.68 ± 1.451***
Diabetic control + Glibenclamide (1 mg/kg b wt.) Group 7	281.1 ± 0.7859***	157.4 ± 1.004***	86.74 ± 1.701***

The data are expressed as mean ± SEM. (n = number of animals in each group = 5). The comparisons were made by one way ANOVA followed by Dunnent’s test.
ns = non-significant, STZ = Streptozotocin.
*p < 0.05 is considered as significant when compared to the control group (0 h).
**p < 0.001 is considered as very significant when compared to the control group (0 h).
***p < 0.001 is considered as extremely significant when compared to the control group (0 h).

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