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Table 4 Plasma metabolites detected in the sham-operated and model animals 45 days after the operation

From: Plasma metabonomics study on Chinese medicine syndrome evolution of heart failure rats caused by LAD ligation

Metabolic pathway

RT (min)

Metabolites

Sham-operated (×109)

Model (×109)

P value

TAC

19.6

Citric acid

9.14 ± 7.010

1.91 ± 1.550

0.020

24.16

cAMP

0.44 ± 0.200

0.13 ± 0.236

0.040

Amino acid metabolism

8.01

Ethylbis(trimethylsilyl)amine

0.37 ± 0.124

0.69 ± 0.134

0.016

9.45

Alanine

0.67 ± 0.250

0.41 ± 0.148

0.015

10.15

Silanamine

2.34 ± 0.423

1.45 ± 0.537

0.041

10.91

L-Norvaline

2.14 ± 0.473

1.02 ± 0.909

0.047

11.67

L-Valine

0.29 ± 0.117

0.12 ± 0.032

0.014

12.00

Urea

4.775 ± 0.851

6.96 ± 1.963

0.086

13.17

Glycine

0.52 ± 0.154

0.24 ± 0.147

0.024

14.11

L-Serine

1.17 ± 0.511

1.67 ± 0.266▲▲

0.001

16.15

L-Proline

0.51 ± 0.104

0.36 ± 0.047

0.036

Glucose metabolism

20.02

Ribitol

0.02 ± 0.053

0.35 ± 0.192▲▲

0.002

22.52

Glucopyranoside

0.16 ± 0.046

0.07 ± 0.017

0.023

Fatty acid metabolism

8.73

Lactic acid

1.27 ± 0.102

1.69 ± 0.319

0.039

14.80

Butanoic acid

0.38 ± 0.080

0.52 ± 0.076

0.028

17.48

Dodecanoic acid

0.56 ± 0.811

0.37 ± 0.209

0.550

21.78

Hexadecanoic acid

2.45 ± 0.483

1.30 ± 0.707

0.023

23.19

Heneicosane

0.74 ± 0.256

0.06 ± 0.181

0.000

23.53

Octadecanoic acid

6.07 ± 0.927

4.28 ± 1.103

0.047

 

28.32

Octadecatrienoic acid

1.25 ± 0.149

0.48 ± 0.309

0.002

  1. Note: increased significantly in model group, P < 0.05 compare with the Sham Group, ▲▲P < 0.01 compare with the Sham Group; decreased significantly in model group, P < 0.05 compare with the Sham Group, P < 0.01 compare with the Sham Group.