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Table 4 Logistic regression analysis for dyslipidemia risk

From: Genetic loci associated with changes in lipid levels leading to constitution-based discrepancy in Koreans

   Combined* KoGES KCMS
     n (MAF)    n (MAF)   
SNP (allele, gene) Subject OR (SE) P-value Control Case OR (SE) P-value Control Case OR (SE) P-value
rs4149270 (C>T, ABCA1) All 1.157 (0.034) 1.55 × 10 -5 2048 (0.330) 3480 (0.359) 1.136 (0.042) 2.49 × 10 -3 1305 (0.275) 1728 (0.366) 1.194 (0.056) 1.55 × 10 -3
  TE 1.185 (0.064) 0.00826 594 (0.305) 1227 (0.350) 1.199 (0.077) 1.84 × 10-2 242 (0.349) 583 (0.387) 1.151 (0.115) 0.222
  NTE 1.126 (0.060) 0.0491 755 (0.342) 1067 (0.364) 1.135 (0.073) 0.0816 499 (0.327) 337 (0.347) 1.106 (0.106) 0.344
rs6589566 (A>G, APOA5) All 1.156 (0.040) 2.77 × 10 -4 2047 (0.203) 3481 (0.224) 1.150 (0.050) 5.13 × 10 -3 1305 (0.203) 1735 (0.228) 1.167 (0.066) 1.99 × 10 -2
  TE 1.148 (0.075) 0.0648 593 (0.205) 1227 (0.222) 1.128 (0.090) 0.182 247 (0.206) 589 (0.235) 1.195 (0.134) 0.185
  NTE 1.222 (0.072) 0.00536 755 (0.203) 1068 (0.224) 1.176 (0.087) 0.0628 493 (0.195) 338 (0.235) 1.328 (0.128) 2.68 × 10-2
rs4420638 (T>C, APOC1) All 1.232 (0.052) 5.53 × 10-5 2050 (0.100) 3478 (0.125) 1.286 (0.065) 9.52 × 10-5 1309 (0.107) 1742 (0.120) 1.140 (0.087) 0.132
  TE 1.158 (0.100) 0.142 593 (0.094) 1227 (0.115) 1.266 (0.122) 0.0528 248 (0.113) 590 (0.114) 0.962 (0.176) 0.828
  NTE 1.186 (0.091) 0.0614 755 (0.109) 1065 (0.131) 1.220 (0.109) 0.0677 495 (0.103) 339 (0.111) 1.110 (0.168) 0.535
rs261332(G>A, LIPC) All 0.883 (0.049) 2.18 × 10-3 2047 (0.226) 3481 (0.214) 0.918 (0.049) 0.0823 1308 (0.225) 1745 (0.198) 0.834 (0.065) 5.38 × 10-3
  TE 0.901 (0.082) 0.177 591 (0.222) 1229 (0.216) 0.959 (0.089) 0.635 248 (0.242) 590 (0.204) 0.807 (0.128) 0.0934
  NTE 0.818 (0.071) 4.68 × 10-3 755 (0.232) 1066 (0.201) 0.810 (0.085) 1.27 × 10-2 495 (0.211) 339 (0.187) 0.839 (0.129) 0.175
rs6586891 (C>A, LPL) All 0.854 (0.034) 4.31 × 10 -6 2051 (0.343) 3485 (0.315) 0.859 (0.043) 4.37 × 10 -4 1304 (0.345) 1739 (0.309) 0.846 (0.057) 3.10 × 10 -3
  TE 0.867 (0.065) 0.0275 594 (0.329) 1230 (0.316) 0.919 (0.078) 0.276 247 (0.360) 590 (0.302) 0.758 (0.118) 0.190
  NTE 0.842 (0.062) 0.00555 755 (0.341) 1069 (0.313) 0.862 (0.076) 4.88 × 10-2 494 (0.333) 338 (0.288) 0.803 (0.108) 4.32 × 10-2
  1. *Combined: combined meta-analysis of association signals in the KoGES and KCMS populations in a fixed effect model.
  2. Superscript p-values indicate significant associations. Significance: p < 0.005 (0.05/10 SNPs) in the combined population; p < 0.05 in the KoGES and KCMS populations.
  3. Boldface letters indicate reproducible associations in all three populations.