Table 4 Logistic regression analysis for dyslipidemia risk
Combined* | KoGES | KCMS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
n (MAF) | n (MAF) | ||||||||||
SNP (allele, gene) | Subject | OR (SE) | P-value† | Control | Case | OR (SE) | P-value† | Control | Case | OR (SE) | P-value† |
rs4149270 (C>T, ABCA1) | All | 1.157 (0.034) | 1.55 × 10 -5 | 2048 (0.330) | 3480 (0.359) | 1.136 (0.042) | 2.49 × 10 -3 | 1305 (0.275) | 1728 (0.366) | 1.194 (0.056) | 1.55 × 10 -3 |
TE | 1.185 (0.064) | 0.00826 | 594 (0.305) | 1227 (0.350) | 1.199 (0.077) | 1.84 × 10-2 | 242 (0.349) | 583 (0.387) | 1.151 (0.115) | 0.222 | |
NTE | 1.126 (0.060) | 0.0491 | 755 (0.342) | 1067 (0.364) | 1.135 (0.073) | 0.0816 | 499 (0.327) | 337 (0.347) | 1.106 (0.106) | 0.344 | |
rs6589566 (A>G, APOA5) | All | 1.156 (0.040) | 2.77 × 10 -4 | 2047 (0.203) | 3481 (0.224) | 1.150 (0.050) | 5.13 × 10 -3 | 1305 (0.203) | 1735 (0.228) | 1.167 (0.066) | 1.99 × 10 -2 |
TE | 1.148 (0.075) | 0.0648 | 593 (0.205) | 1227 (0.222) | 1.128 (0.090) | 0.182 | 247 (0.206) | 589 (0.235) | 1.195 (0.134) | 0.185 | |
NTE | 1.222 (0.072) | 0.00536 | 755 (0.203) | 1068 (0.224) | 1.176 (0.087) | 0.0628 | 493 (0.195) | 338 (0.235) | 1.328 (0.128) | 2.68 × 10-2 | |
rs4420638 (T>C, APOC1) | All | 1.232 (0.052) | 5.53 × 10-5 | 2050 (0.100) | 3478 (0.125) | 1.286 (0.065) | 9.52 × 10-5 | 1309 (0.107) | 1742 (0.120) | 1.140 (0.087) | 0.132 |
TE | 1.158 (0.100) | 0.142 | 593 (0.094) | 1227 (0.115) | 1.266 (0.122) | 0.0528 | 248 (0.113) | 590 (0.114) | 0.962 (0.176) | 0.828 | |
NTE | 1.186 (0.091) | 0.0614 | 755 (0.109) | 1065 (0.131) | 1.220 (0.109) | 0.0677 | 495 (0.103) | 339 (0.111) | 1.110 (0.168) | 0.535 | |
rs261332(G>A, LIPC) | All | 0.883 (0.049) | 2.18 × 10-3 | 2047 (0.226) | 3481 (0.214) | 0.918 (0.049) | 0.0823 | 1308 (0.225) | 1745 (0.198) | 0.834 (0.065) | 5.38 × 10-3 |
TE | 0.901 (0.082) | 0.177 | 591 (0.222) | 1229 (0.216) | 0.959 (0.089) | 0.635 | 248 (0.242) | 590 (0.204) | 0.807 (0.128) | 0.0934 | |
NTE | 0.818 (0.071) | 4.68 × 10-3 | 755 (0.232) | 1066 (0.201) | 0.810 (0.085) | 1.27 × 10-2 | 495 (0.211) | 339 (0.187) | 0.839 (0.129) | 0.175 | |
rs6586891 (C>A, LPL) | All | 0.854 (0.034) | 4.31 × 10 -6 | 2051 (0.343) | 3485 (0.315) | 0.859 (0.043) | 4.37 × 10 -4 | 1304 (0.345) | 1739 (0.309) | 0.846 (0.057) | 3.10 × 10 -3 |
TE | 0.867 (0.065) | 0.0275 | 594 (0.329) | 1230 (0.316) | 0.919 (0.078) | 0.276 | 247 (0.360) | 590 (0.302) | 0.758 (0.118) | 0.190 | |
NTE | 0.842 (0.062) | 0.00555 | 755 (0.341) | 1069 (0.313) | 0.862 (0.076) | 4.88 × 10-2 | 494 (0.333) | 338 (0.288) | 0.803 (0.108) | 4.32 × 10-2 | |