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Table 2 Linear regression analysis for lipid traits in the Korean population

From: Genetic loci associated with changes in lipid levels leading to constitution-based discrepancy in Koreans

    Combined KoGES KCMS
SNP (allele, gene) MAF Trait* n Effect (SE) [mg/dL] P-value n Effect (SE) [mg/dL] P-value n Effect (SE) [mg/dL] P-value
rs4149270 (C>T, ABCA1) 0.348 HDLC 8554 -0.956 (0.187) 3.10 × 10 -7 5528 -0.806 (0.236) 6.51 × 10 -4 3026 -1.205 (0.305) 7.93 × 10 -5
rs10889353 (A>C, ANGPTL3) 0.173 TG 8575 -0.018 (0.004) 3.25 × 10-5 5536 -0.021 (0.005) 1.18 × 10-4 3039 -0.013 (0.007) 0.0739
rs1748195 (C>G, ANGPTL3) 0.221 TG 8582 -0.016 (0.004) 6.28 × 10 -5 5536 -0.018 (0.005) 4.83 × 10 -4 3046 -0.013 (0.007) 4.36 × 10 -2
rs6589566 (A>G, APOA5) 0.217 TG 8569 0.044 (0.004) < 2.0 × 10 -16 5528 0.043 (0.005) < 2.0 × 10 -16 3041 0.046 (0.007) 7.25 × 10 -12
   HDLC 8569 -0.963 (0.220) 1.22 × 10 -5 5528 -0.935 (0.278) 7.65 × 10 -4 3041 -1.009 (0.361) 5.19 × 10 -3
rs4420638 (T>C, APOC1) 0.115 LDLC 8579 4.103 (0.752) 4.87 × 10 -8 5528 4.287 (0.951) 6.61 × 10 -6 3051 3.796 (1.230) 2.04 × 10 -3
   TG 8579 0.018 (0.005) 4.80 × 10 -4 5528 0.016 (0.0006) 1.47 × 10 -2 3051 0.023 (0.009) 1.01 × 10 -2
   HDLC 8579 -1.108 (0.283) 8.87 × 10 -5 5528 -0.983 (0.353) 5.41 × 10 -3 3051 -1.329 (0.283) 4.80 × 10 -3
rs174547 (T>C, FADS1) 0.330 TG 8575 0.014 (0.004) 6.25 × 10 -5 5533 0.014 (0.004) 1.45 × 10 -3 3042 0.014 (0.006) 1.54 × 10 -2
rs3846663 (T>C, HMGCR) 0.473 LDLC 8587 -1.871 (0.477) 8.75 × 10 -5 5537 -1.872 (0.611) 2.21 × 10 -3 3050 -1.871 (0.763) 1.42 × 10 -2
rs261332 (G>A, LIPC) 0.215 TG 8578 0.014 (0.004) 8.84 × 10 -4 5528 0.012 (0.005) 1.51 × 10 -2 3050 0.015 (0.007) 2.17 × 10 -2
   HDLC 8578 1.233 (0.219) 1.90 × 10 -8 5528 1.124 (0.278) 5.36 × 10 -5 3050 1.413 (0.357) 7.78 × 10 -5
rs2156552 (A>T, LIPG) 0.164 HDLC 8583 -0.884 (0.242) 2.61 × 10-4 5536 -1.019 (0.309) 9.84 × 10-4 3047 -0.670 (0.390) 0.0858
rs1919484 (G>A, LPL) 0.208 TG 8577 -0.019 (0.004) 3.68 × 10 -6 5535 -0.016 (0.005) 2.12 × 10 -3 3042 -0.025 (0.007) 3.02 × 10 -4
   HDLC 8577 1.062 (0.220) 1.45 × 10 -6 5535 0.733 (0.277) 8.04 × 10 -3 3042 1.633 (0.365) 7.85 × 10 -6
rs6586891 (C>A, LPL) 0.325 TG 8579 -0.016 (0.004) 5.56 × 10 -6 5536 -0.015 (0.004) 7.91 × 10 -4 3043 -0.018 (0.006) 2.04 × 10 -3
   HDLC 8579 1.096 (0.191) 9.39 × 10 -9 5536 1.031 (0.242) 2.13 × 10 -5 3043 1.203 (0.310) 1.07 × 10 -4
rs17321515 (G>A, TRIB1) 0.439 TG 8573 0.013 (0.003) 1.59 × 10-4 5528 0.015 (0.0004) 3.19 × 10-4 3045 0.008 (0.006) 0.136
  1. *Triglyceride (TG): log-transformed.
  2. Combined: combined meta-analysis of association signals in the KoGES and KCMS populations in a fixed effect model.
  3. Superscript p-values indicate significant associations. Significance: p < 0.00192 (0.05/26 SNPs) in the combined population; p < 0.05 in the KoGES and KCMS populations.
  4. Boldface letters indicate reproducible associations in all three populations.