The effects of Aloe vera improved liver histopathology (hematoxylin and eosin stain). A: Control group showed normal hepatic architecture (× 40). B: N-acetyl-P-aminophenol (APAP) group showed acute centrilobular hemorrhagic hepatic necrosis through all zones (zones 1, 2, and 3) (× 40). C: Aloe vera-treated group showed focal necrosis with mild fatty changes and hepatic architecture was well preserved with limited hepatic change (× 40). Arrows indicate hepatic necrosis and CV indicate central vein.