Figure 7

AVO inhibits the growth of various cancer cell lines by inducing a caspase-dependent apoptosis. Jurkat, K562, MCF-7, HepG2, PC-3 and HeLa cells were treated with varying concentrations (0.0-2.0 μg/mL) of AVO-b (A) or AVO-l (B) and the viability was analyzed by MTT assay. The data shown represent the mean ± SD of three independent experiments. (C) Extracts (30 μg proteins) from these cancer cells treated with 1.0 μg/mL of AVO-b or AVO-l were analyzed for caspase-3 catalytic activities. The specific enzyme activities, which represent the mean ± SD of three independent experiments, were measured as described in the methods. *p < 0.01 of statistically insignificant values, when compared to untreated samples.