Table 2 Effect of extracts from roots/rhizomes of C. articulatus on O. ochengi in primary screens
From: Anti-Onchocerca activity and phytochemical analysis of an essential oil from Cyperus articulatus L
Test substance (concentration tested) | % Microfilarial motility reduction | % Adult male worm motility reduction | % Adult female worm death | Comment |
|---|---|---|---|---|
CARhex (500 μg/ml) | 100 | 100 | 100 | Macro- and microfilaricidal |
CARmc (500 μg/ml) | 25 | 50 | 25 | Inactive |
CARmet (500 μg/ml) | 25 | 75 | 25 | Inactive on Mfs and adult females; moderately active on adult males |
Ivermectin (10 μg/ml) | 100 | NA | NA | Microfilaricidal |
NYBC01 (10 μM) | 100 | 100 | 100 | Macro- and microfilaricidal |
DMSO (2%) | 0 | 0 | 0 | Inactive |