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Table 4 Micronucleus test in mice following a single oral dose of Guibi-Tang (GBT) extract

From: Genotoxicity evaluation of Guibi-Tang extract using an in vitro bacterial reverse mutation assay, chromosome aberration assay, and in vivo micronucleus test

Group Vehicle control GBT GBT GBT Positive control (cyclophosphamide)
Dose (mg/kg) 0 500 1000 2000 70
MNPCE/2000PCEs (Mean ± S.D) 0.33 ± 0.58 1.67 ± 1.15 1.00 ± 1.00 0.33 ± 0.58 62.33* ± 10.21
PCE/(PCE+NCE) (Mean ± S.D) 0.48 ± 0.05 0.53 ± 0.07  0.50 ± 0.08 0.53 ± 0.05 0.46 ± 0.03 
Number of animals 3 3 3 3 3
  1. MNPCE: PCE with one or more micronuclei; PCE: Polychromatic erythrocyte; NCE: Normochromatic erythrocyte.
  2. *Significantly different from the control at p<0.05.