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Table 2 The ratio of combined GTT and HC compounds at growth inhibition of 50% (IC50) on glioma cancer 1321N1, SW1783, LN18 cells and combination index (CI) for each combination

From: Gamma-tocotrienol and hydroxy-chavicol synergistically inhibits growth and induces apoptosis of human glioma cells

Type of cell line GTT:HC IC50a[μg/ml] GTTb[μg/ml] HCb[μg/ml] Combination Indexc(CI)
1321N1 10 : 3 12 100 75 0.55 ± 0.07
SW1783 20 : 1 2 79 95 0.54 ± 0.03
LN18 2 : 3 29 42 119 0.73 ± 0.03
  1. aIC50 of combined compounds.
  2. bIC50 of individual compound.
  3. cCI < 1.0 indicates synergism; 0.9 < CI < 1.10, near additive; CI > 1.10 indicates antagonism.
  4. The data are the average of three independent experiments.