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Table 4 Biochemical and hematological parameters of Swiss mice exposed to the EAF fraction of A. sylvatica in the acute toxicity study

From: Evaluation of the anti-mycobacterium tuberculosis activity and in vivo acute toxicity of Annona sylvatic

Parameters

Control

500 mg kg-1

1000 mg kg-1

2000 mg kg-1

p*

Creatinine (mg/dL)

0.29 ± 0.03

0.29 ± 0.07

0.28 ± 0.06

0.28 ± 0.05

0.8100

Urea (mg/dL)

43.66 ± 4.27

44.33 ± 4.41

45 ± 5.03

42.5 ± 4.23

0.6391

AST (U/L)

76 ± 4.45

78 ± 5.91

77 ± 4.94

79 ± 4.99

0.9015

ALT (U/L

52.5 ± 4.27

48.5 ± 4.37

50 ± 4.27

53 ± 4.75

0.1990

γ GT (U/L)

11 ± 1.41

11.5 ± 1.37

11 ± 1.26

12 ± 12.6

0.5218

RBC (x 106/mm3)

7.06 ± 0.12

7.11 ± 0.11

7.1 ± 0.10

7.15 ± 0.08

0.6161

HT (%)

45.33 ± 3.66

44.68 ± 3.55

44.5 ± 2.81

45.16 ± 3.9

0.9721

WBC (%)

8.16 ± 0.75

8.33 ± 1.03

8 ± 0.63

8.33 ± 0.81

0.4138

PLT (x 103/μL)

916 ± 10.78

928 ± 9.77

928.66 ± 27

925.16 ± 13

0.5353

LYNF (%)

77 ± 1.63

71±1.36

77.83 ± 0.89

79 ± 2.06

0.4913

NEUT (%)

19.16 ± 1.02

20 ± 1.69

19 ± 0.13

17 ± 1.14

0.5783

  1. Hematological and biochemical parameters of female Swiss mice treated acutely orally with vehicle (control) or the EAF fraction of A. sylvatica at doses of 500 mg kg-1 1000 mg kg-1 and 2000 mg kg-1 Values represent the mean ± SD. (n=6) is the number of animals in each group. p*=5%.
  2. AST = Aspartate aminotransferase.
  3. ALT = Alanine aminotransferase.
  4. γ GT = Gamma glutamyl transferase.
  5. RBC = Red Blood Cell.
  6. HT = Hematocrite.
  7. WBC = White Blood Cell.
  8. PLT= Platelets.
  9. LYNF = Lymphocytes.
  10. NEUT = Neutrophils.