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Table 1 Effects of CT extract (100, 200 mg/kg) or donepezil (0.75 mg/kg) on the levels of cortical and hippocampal neurotransmitters and their metabolites in Aβ 1-42-infused rats

From: Reversal by aqueous extracts of Cistanche tubulosa from behavioral deficits in Alzheimer’s disease-like rat model: relevance for amyloid deposition and central neurotransmitter function

 

The levels in cortex (nmol/mg protein for ACh and choline, ng/g protein for other transmitters)

 

ACh

Choline

MHPG

NE

DOPAC

HVA

DA

Vehicle

224.25 ± 25.55**

629.00 ± 98.35

26.35 ± 2.72

15.68 ± 0.76

16.75 ± 1.70*

3.71 ± 0.58

3.92 ± 0.44**

Aβ 1-42

141.35 ± 7.95

553.10 ± 31.55

23.27 ± 1.97

13.86 ± 1.29

11.66 ± 1.13

2.76 ± 0.43

2.33 ± 0.28

CT extract

 

 100 mg/kg

145.98 ± 18.78

716.40 ± 69.81

29.91 ± 4.91

15.94 ± 1.30

13.89 ± 3.03

4.29 ± 0.93

2.95 ± 0.65

 200 mg/kg

181.49 ± 13.71*

693.45 ± 48.05

24.51 ± 4.16

10.31 ± 1.07

9.50 ± 2.10

2.98 ± 0.85

2.23 ± 0.33

Donepezil

168.32 ± 6.58*

467.26 ± 32.85

15.16 ± 2.51*

10.73 ± 2.33

10.49 ± 2.38

2.42 ± 0.78

3.10 ± 0.46

 

The levels in hippocampus (nmol/mg protein for ACh and choline, ng/g protein for other transmitters)

 

ACh

Choline

MHPG

NE

DOPAC

HVA

DA

Vehicle

72.88 ± 8.64***

295.26 ± 18.06**

639.83 ± 53.38

63.64 ± 2.56*

5.87 ± 0.92

3.68 ± 0.41

5.36 ± 0.75***

Aβ 1-42

28.45 ± 2.62

173.10 ± 18.15

639.23 ± 68.26

52.67 ± 4.21

5.13 ± 0.80

3.39 ± 0.36

1.00 ± 0.21

CT extract

 

 100 mg/kg

43.48 ± 3.14

238.20 ± 23.91

785.42 ± 139.84

57.98 ± 10.69

4.98 ± 0.78

3.90 ± 0.61

2.40 ± 0.65*

 200 mg/kg

50.44 ± 8.98*

234.69 ± 13.26

704.84 ± 59.68

63.21 ± 4.79

5.98 ± 1.90

3.78 ± 0.64

3.09 ± 1.27*

Donepezil

51.11 ± 9.54*

177.69 ± 46.80

455.27 ± 46.81*

32.80 ± 3.88***

3.19 ± 1.00

2.45 ± 0.33

1.33 ± 0.37

  1. Columns indicate means ± SEM (N = 6). *P < 0.05, **P < 0.01, ***P < 0.001 compared with Aβ 1-42-infused rats.