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Table 1 Effect of adrenalectomy on the rhodiola-water extract-induced changes of β-endorphin-like immunoreactivity (BER) and plasma glucose concentration in STZ-diabetic rats

From: Antihyperglycemic action of rhodiola-aqeous extract in type1-like diabetic rats

  Sham-operated group Adrenalectomized group
Plasma glucose (mg/dL)   
Basal 378.6 ± 5.3 375.0 ± 4.6
Vehicle 370.5 ± 6.9 366.5 ± 5.0
Rhodiola-water extract (75 mg/kg) 254.0 ± 2.4*** 373.5 ± 5.8
Plasma BER (pg/mL)   
Basal 70.5 ± 2.1 69.8 ± 1.2
Vehicle 68.5 ± 1.8 69.0 ± 1.4
Rhodiola-water extract (75 mg/kg) 84.3 ± 1.3*** 68.7 ± 1.2
  1. Blood samples from STZ-diabetic rats receiving an intraperitoneal injection of rhodiola-water extract or a vehicle-treated control were used for determination of β-endorphin-like immunoreactivity (BER) and the plasma glucose concentration. Vehicle (0.9% saline) was given at the same volume. Values (mean ± S.E.M.) were obtained from each group of eight rats. Basal level shows the value from fasted animals without treatment. ***p < 0.001 versus basal value in each group.