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Table 1 Effect estimate of Guizhi Fuling Formula for volume of uterine fibroids

From: Chinese herbal medicine Guizhi Fuling Formula for treatment of uterine fibroids: a systematic review of randomised clinical trials

Parameters representing the volume of fibroids Study ID MD [95% CI] P value
Guizhi Fuling Formula versus mifepristone
Average volume of maximum fibroids Zhu YJ [30] −1.43 [−3.23, 0.37] 0.12
Total volume of multiple fibroids aGao CR b [14] −3.00 [−16.65, 10.65] 0.67
Average volume of multiple fibroids Xiong DM [31] 0.50 [0.12, 0.88] 0.01
Volume of fibroids without clarified parameters bHu WH a [15] 0.19 [−0.12, 0.50] 0.22
cHu WH b [15] −0.62 [−0.86,-0.38] <0.00001
Guizhi Fuling Formula plus mifepristone versus mifepristone
Average volume of maximum fibroids Chen XJ [32] −0.60 [−1.19, -0.01] 0.05
Gu Y [33] −0.83 [−1.50, -0.16] 0.02
Teng MJ [34] −19.36 [−24.33, -14.39] <0.00001
Wu YF [35] −4.34 [−7.48, -1.20] 0.007
Yang ZQ [36] −0.58 [−1.16, -0.00] 0.05
Yue Li [37] −2.32 [−5.35, 0.71] 0.13
Zhao YF [19] −3.28 [−4.47, -2.09] <0.00001
Zhong GP [38] −6.75 [−9.19, -4.31] <0.00001
Subgroup meta-analysis (random, I2 = 93%) −3.35 [−4.84, -1.87] <0.00001
Total volume of multiple fibroids aGao CR a [14] −15.00 [−28.95,-1.05] 0.04
Lu HJ [39] −22.90 [−35.31,-10.49] 0.0003
Subgroup meta-analysis (fixed, I2 = 0%) −19.41 [−28.68,-10.14] <0.0001
Average volume of multiple fibroids Chen LQ [21] −1.03 [−1.40, -0.66] <0.00001
Gu HH [16] −0.87 [−1.32, -0.42] 0.0001
Xiong DM [24] −1.06 [−1.48, -0.64] <0.00001
Subgroup meta-analysis (fixed, I2 = 0%) −1.00 [−1.23, -0.76] <0.00001
Volume of fibroids without clarified parameters Deng XL [22] −0.68 [−2.38, 1.02] 0.43
Li LJ [40] −2.00 [−16.17, 12.17] 0.78
Luan F [20] −0.68 [−1.95, 0.59] 0.29
Mao CX [41] −0.85 [−1.09, -0.61] <0.00001
Mao XG [23] −7.10 [−10.14, -4.06] <0.00001
Wang JY [42] −5.40 [−8.73, -2.07] 0.001
Wang XR [18] −1.35 [−1.77, -0.93] <0.00001
Wu JH [43] −3.10 [−4.18, -2.02] <0.00001
Ying LJ [25] −1.24 [−2.55, 0.07] 0.06
Zhang LY [26] −1.11 [−2.46, 0.24] 0.11
  1. aGao CR with three arms had two comparisons. bHu WH a: Guizhi Fuling capsules were taken 3# three times daily for 6 months; cHu WH b: Guizhi Fuling capsules were taken 5# three times daily for 2 months and 3# three times daily for 4 months.