Representative images of the sponge implant disc. Sponge disc before implantation in the peritoneal cavity (A). In (B) sponge disc 5 days after implantation. The implant is extensively adhered to the intestine and liver by a bridge of fibrous tissue. In C and D representative histological sections (5 μm, stained with Gomori Trichrome) of intraperitoneal implant. The matrix of the synthetic sponge is occupied with inflammatory cells, spindle-shaped cells and blood vessels. The fibrovascular tissue in implants of non-treated mice (C) is denser and more vascularized than the treated implant (D). Black arrow: blood vessels; *: The sponge material is seen as triangular objects under the microscope; 60x; Bar: 50 μm.