Morphologic analysis by transmission electron microscopy of control cells and cells treated with 10 μg/ml of seed extract for 24 h. (A) Representative image of control cells. Some vesicles are present in the cytoplasm. (B) Control cells at a higher magnification. (C) and (D) Treated cells. Autophagic vacuoles and electron-dense bodies can be observed in the cytoplasm. The nucleus in (D) is normal. Bar = 1 μm. N = nucleus, Nu = nucleolus, M = mitochondria, V = vesicle, ER = endoplasmic reticulum, AV = autophagic vesicle, EB = electron-dense body.