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Table 1 In- and exclusion criteria for the participation at the study

From: Perilla Extract improves gastrointestinal discomfort in a randomized placebo controlled double blind human pilot study

Inclusion criteria Exclusion criteria
Healthy volunteers without clinical diagnosed diseases with relevant effect on the gastrointestinal system or on visceral motility Subject under prescription for medication for digestive symptoms such as anti-spasmodic, laxatives and anti-diarrheic drugs or other digestive auxiliaries
Reduced bowel movements defined as an average of >1 and ≤ 3.5 stools per week for at least the previous 6 months Relevant history, presence of any medical disorder or intake of medication/dietary supplements, potentially interfering with this trial at screening
BMI: 19-30 kg/m2 Subjects with stool frequency of ≤ 1 stool every 7 days or > 3.5 stools per week
Gastrointestinal symptoms of at least 5 points Subjects not willing to avoid pre- and probiotics for the duration of the study
Male or female Intake of antibiotics in the last 4 weeks and laxatives in the last 2 weeks
Age ≥ 30 and ≤ 70 years Change of dietary habits within the 4 weeks prior to screening (for instance start of a diet high in fibers)
Nonsmoker Pregnant subject or subject planning to become pregnant during the study; breast-feeding subject
Written consent to participate in the study Subjects with history of drug, alcohol or other substances abuse, or other factors limiting their ability to co-operate during the study
Able and willing to follow the study protocol procedures Participants anticipating a change in their lifestyle or physical activity levels since this may also influence the results
  Known food intolerance or allergy
  Subject involved in any clinical or food study within the preceding month