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Table 3 Antimalarial activity of plumbagin compared with chloroquine and negative control (treated with 20% Tween-80) against P. berghei ANKA strain in mice (4-day suppressive test)

From: Antimalarial activity of plumbagin in vitro and in animal models

Treatment Dose (mg/kg body weight/day) Parasite density (range: %) on day 4 % Suppression at day 4 Survival time (days)
Negative control (20% Tween 80) - 37.8 (46.9-41.8)a 0 7 (6–7)
Plumbagin 1 35.6 (31.7–39.6) 5.8 7.5 (6–9)
10 35.05 (31.2–38.8) 7.3 8 (8–9)
25 22.3 (19.2–25.7) 41 10 (9–11)
Chloroquine 10 0 (0–0)b 100c > 15d
  1. Data are presented as median (range) values (6 mice for each group) of parasite density, % suppression and survival time.
  2. a Significantly lower than the groups treated with 10 and 25 mg/kg body weight/day of plumbagin and 10 mg/kg body weight/day of chloroquine (p < 0.05).
  3. b Significantly higher than negative control and the groups treated with 1, 10 and 25 mg/kg body weight/day of plumbagin (p < 0.05).
  4. c Significantly higher than negative control and the groups treated with 1, 10 and 25 mg/kg body weight/day of plumbagin (p < 0.05).
  5. d Significantly longer than the groups treated with 1, 10 and 25 mg/kg body weight/day of plumbagin and 10 mg/kg body weight/day chloroquine (p < 0.05).