Astragalus injection had effects on the protein expression of Smad3, Smad7, TGFβ1, and TGFβR-I. Protein extracts from the renal cortex were analyzed to evaluate the expression of TGFβ/Smad proteins. The reduction in Smad3 and TGFβR-I protein levels was similarly observed in diabetic mice after astragalus treatment, but no significant change was observed in the TGFβ1 level. CG = the control group, MG = the model group, and TG = the astragalus group. Compared with CG, *P < 0.05, **P < 0.01. Compared with MG, Δ
P < 0.05,
P < 0.01.