Astragalus injection had effects on the mRNA expression of Smad3, Smad7, TGFβ1, and TGFβR-I. Mice were sacrificed at week 24. The MG showed decreased expression of Smad7 and increased expression of Smad3, TGFβR-I, TGFβ1. Data presented are means ± SD (n = 3). CG = the control group, MG = the model group, and TG = the astragalus group. Compared with CG, *P < 0.05, **P < 0.01. Compared with MG, Δ
P < 0.05, ΔΔ
P < 0.01.