Sho-saiko-to, a traditional herbal medicine, regulates gene expression and biological function by way of microRNAs in primary mouse hepatocytes

Song, Kwang Hoon; Kim, Yun Hee; Kim, Bu-Yeo

doi:10.1186/1472-6882-14-14

BMC Complementary Medicine and Therapies

Table 1 The microRNA targets regulated by SST

From: Sho-saiko-to, a traditional herbal medicine, regulates gene expression and biological function by way of microRNAs in primary mouse hepatocytes

Temporal up-pattern
MicroRNA*	Target symbol	Target entrez	MicroRNA	Target symbol	Target entrez	MicroRNA	Target symbol	Target entrez
miR-495-3p	Depdc1b	218581	miR-19b-2-5p	Sprr2a2	1E + 08	miR-3089-3p	Scara3	219151
	Slc1a2	20511		Mbnl3	171170		Rad51	19361
	Steap2	74051		Cep55	74107	miR-3095-5p	Gsta3	14859
	Zmat1	215693		Tia1	21841		Ccnd1	12443
	Fmo5	14263	miR-3092-5p	Cln6	76524	miR-30c-5p	Fam43a	224093
	Ckap4	216197		Lass3	545975		Fam49a	76820
	Bcl2l15	229672		Gsto1	14873	miR-322-3p	Ugdh	22235
	Bst1	12182		C1qtnf1	56745		Mybl1	17864
	Pttg1	30939	miR-450a-2-3p	Slc7a2	11988	miR-343	Mybl2	17865
	Osbpl3	71720		Slc1a2	20511		Nfasc	269116
	Esco2	71988		Steap2	74051	miR-380-5p	Cdon	57810
	4930547N16Rik	75317		Dcdc2a	195208		Ccdc89	70054
miR-669d-3p	Cenpi	102920	miR-466 k	Zscan29	99334	miR-410-3p	Pla2r1	18779
	Cysltr1	58861		Dcdc2a	195208		Sema3e	20349
	Gnai1	14677		Ptchd1	211612	miR-449a-5p	Gpr64	237175
	Zmat1	215693		Saa4	20211		H6pd	100198
	Rgs4	19736	miR-653-3p	Igf2bp1	140486	miR-466n-3p	Mest	17294
	Kif23	71819		Nfasc	269116		Dcdc2a	195208
	Fam55c	385658		Ect2	13605	miR-467 g	Cxcl5	20311
	Birc5	11799		Lox	16948		Dcdc2a	195208
	Aspm	12316	miR-669 h-3p	Snap25	20614	miR-5113	Gbp4	17472
	Bub1	12235		Steap2	74051		Slc7a2	11988
	Oip5	70645		Cysltr1	58861	miR-670-3p	Evl	14026
	Ckap2	80986		Rgs4	19736		Bcl2l15	229672
miR-98-3p	Clspn	269582	miR-697	Ckap4	216197	miR-692	Marcks	17118
	Zfpm2	22762		Slc1a2	20511		Dcdc2a	195208
	Nfasc	269116		Fzd8	14370	miR-693-3p	Akr1c14	105387
	Ect2	13605		Klf15	66277		Nfasc	269116
	Ccna2	12428	miR-881-5p	Serpine1	18787	miR-701-3p	1700029I01Rik	70005
	Rad51	19361		Slc1a2	20511		Dcdc2a	195208
	Dock11	75974		Steap2	74051	miR-758-3p	Tpx2	72119
miR-21-3p	Nuf2	66977		Fmo5	14263		Zfpm2	22762
	Steap2	74051	miR-9-5p	Fam132b	227358	miR-875-3p	Cxcl3	330122
	Zfpm2	22762		Lhfp	108927		Ehf	13661
	Fgf13	14168		Galnt3	14425	miR-122-5p	Samd5	320825
	Sema3e	20349		Sort1	20661	miR-134-5p	H6pd	100198
	Top2a	21973	let-7f-2-3p	Gm13154	433804	miR-182-3p	Lhfpl2	218454
miR-30b-5p	Igf2bp1	140486		Fam164a	67306	miR-188-5p	Rspo3	72780
	Slc1a2	20511		Ypel1	106369	miR-1892	Slc7a2	11988
	Cysltr1	58861	miR-107-3p	Rttn	246102	miR-1897-5p	Marcks	17118
	Gnai1	14677		Zfpm2	22762	miR-193-3p	Abcc4	239273
	Lox	16948		Shcbp1	20419	miR-193-5p	Tspyl3	241732
	Nedd4l	83814	miR-124-5p	Klhl13	67455	miR-1950	Axl	26362
miR-30d-5p	Prr11	270906		Steap2	74051	miR-1953	Steap2	74051
	Cysltr1	58861		Cd24a	12484	miR-195-3p	Cebpd	12609
	Gnai1	14677	miR-1947-3p	Prrx1	18933	miR-200a-5p	Fgf13	14168
	Lox	16948		Slc1a2	20511	miR-200b-3p	Lhfp	108927
	Rnf219	72486		Steap2	74051	miR-203-5p	Abcc4	239273
	Nedd4l	83814	miR-200a-3p	Thbd	21824	miR-206-3p	Nedd9	18003
miR-466a-5p	Prc1	233406		Mbnl3	171170	miR-214-3p	Slc7a2	11988
	Slc1a2	20511		Lhfp	108927	miR-216b-3p	Akr1c14	105387
	Steap2	74051	miR-291b-3p	Rtn1	104001	miR-25-5p	Zfp365	216049
	Fam55c	385658		Kif23	71819	miR-298-3p	Ccdc89	70054
	Fgf23	64654		Kit	16590	miR-29c-3p	Pxdn	69675
	Amotl1	75723	miR-29b-2-5p	Fam55c	385658	miR-3062-5p	Ccdc89	70054
miR-466o-3p	Gtse1	29870		Gnai1	14677	miR-3063-5p	Pak3	18481
	Zmat1	215693		Zmat1	215693	miR-3064-5p	Fbln2	14115
	Kif23	71819	miR-466i-3p	Tnfaip2	21928	miR-3075-3p	Wisp1	22402
	Aspm	12316		Slc7a2	11988	miR-3085-3p	Abcc1	17250
	Gpr64	237175		Gbp4	17472	miR-3094-5p	Fgf23	64654
	Serpinb1b	282663	miR-669c-3p	Tnfaip2	21928	miR-3103-3p	Scarf2	224024
miR-669 l-3p	Bmf	171543		Slc7a2	11988	miR-3112-5p	Ptchd1	211612
	Fzd8	14370		Adm	11535	miR-322-5p	Fam164a	67306
	Kit	16590	miR-669e-3p	Tia1	21841	miR-326-5p	Aif1l	108897
	Serpinb1b	282663		Fgf13	14168	miR-335-5p	Gclc	14629
	Trim59	66949		Pak3	18481	miR-3473d	B4galt6	56386
	Bmper	73230	miR-101a-3p	Sult4a1	29859	miR-363-3p	Adm	11535
miR-30a-5p	Prr11	270906		Mbnl3	171170	miR-376c-5p	Prrx1	18933
	Cysltr1	58861	miR-101a-5p	Klhl13	67455	miR-378-3p	Sema3e	20349
	Gnai1	14677		Mbnl3	171170	miR-378b	Igf2bp3	140488
	Rnf219	72486	miR-101b-3p	Sult4a1	29859	miR-380-3p	Mbnl3	171170
	Nedd4l	83814		Mbnl3	171170	miR-382-3p	Sdpr	20324
miR-30e-5p	Prr11	270906	miR-105	Ect2	13605	miR-409-3p	Akr1c14	105387
	Cysltr1	58861		Zfpm2	22762	miR-431-5p	Klf15	66277
	Gnai1	14677	miR-142-5p	Depdc1a	76131	miR-463-5p	Pla2r1	18779
	Lox	16948		Igf2bp3	140488	miR-466i-5p	Dcdc2a	195208
	Rnf219	72486	miR-181b-1-3p	Fgf13	14168	miR-466 l-3p	Snhg11	319317
miR-543-3p	Mlf1	17349		Slc1a2	20511	miR-470-5p	Steap4	117167
	Slc1a2	20511	miR-1912-3p	Gpr137b	83924	miR-484	Csf1	12977
	Cysltr1	58861		Ptchd1	211612	miR-496-3p	Tspan8	216350
	Fut4	14345	miR-1942	Mxra8	74761	miR-499-5p	Cdk1	12534
	Kifc2	16581		Zfpm2	22762	miR-5101	Il5ra	16192
let-7a-2-3p	4930486L24Rik	214639	miR-1a-1-5p	Ehf	13661	miR-5125	Mllt11	56772
	Sema3e	20349		Dcdc2a	195208	miR-5127	Col4a5	12830
	Cd24a	12484	miR-1b-5p	Ugt2b35	243085	miR-5133	Rasl12	70784
	Pamr1	210622		Tlr4	21898	miR-544-3p	Snhg11	319317
miR-137-3p	Glis2	83396	miR-219-5p	Tnfsf15	326623	miR-675-3p	Mbnl3	171170
	Nfasc	269116		Gprc5b	64297	miR-677-5p	Gclc	14629
	Cep55	74107	miR-26a-5p	Hpgd	15446	miR-712-5p	Cep55	74107
	Birc5	11799		Rgs4	19736	miR-7a-5p	Mlph	171531
miR-149-5p	B4galt6	56386	miR-294-3p	Lass3	545975	miR-877-3p	Npr3	18162
	Pak3	18481		Zfpm2	22762	miR-879-5p	Hmmr	15366
	Il5ra	16192	miR-29a-3p	Col5a3	53867	miR-881-3p	Ehf	13661
	Axl	26362		Ppic	19038
miR-194-5p	Gas2l3	237436	miR-3066-5p	Gpt2	108682
	Fam164a	67306		Ccna2	12428
	Ppic	19038	miR-3071-5p	Igf2bp1	140486
	Trim59	66949		Mbnl3	171170
miR-1964-5p	Csdc2	105859	miR-204-3p	Kirrel3	67703	miR-465c-5p	Ugt2b1	71773
	Kirrel3	67703	miR-23a-3p	Cyp3a11	13112	miR-466b-3p	Oas3	246727
let-7e-5p	Cyp2c50	107141	miR-295-5p	Aldob	230163	miR-466f-3p	Npat	244879
miR-126-5p	Ugt3a2	223337	miR-30e-3p	Cyp2f2	13107	miR-466 m-3p	Oas3	246727
miR-181a-5p	Nipal1	70701	miR-328-5p	Cyp2d22	56448	miR-5131	Ccdc85b	240514
miR-181b-5p	Nipal1	70701	miR-344f-5p	Scd1	20249	miR-551b-5p	5033411D12Rik	192136
miR-1960	Mrc1	17533	miR-3470a	Dnahc17	69926	miR-676-5p	Slc27a5	26459
miR-19b-1-5p	Npat	244879	miR-465a-5p	Ugt2b1	71773	miR-707	Slco1a1	28248

^*The MicroRNA name is obtained from the MicroRNA Database (miRDB version 4.0) website (http://mirdb.org) [27, 28].

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ISSN: 2662-7671

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