Figure 3
From: Antioxidant effect of Phyllanthus emblica extract prevents contrast-induced acute kidney injury
Histopathological with H& E staining of CI-AKI in rats. A and B show normal rat kidneys in the cortex and medulla. Rats induced with CM (C and D) demonstrate severe TEC necrosis, moderate PTC congestion (black arrows) and proteinaceous casts (green arrows) in the cortex and medulla. Rats induced with CM and pre-treatment with PE extract 250 mg/kg/day (E and F) show a decrease in the severity of TEC necrosis, PTC congestion, and proteinaceous casts in the cortex and medulla. Interestingly, rats induced with CM and pre-treatment with PE extract 500 mg/kg/day (G and H) demonstrate minimal TEC necrosis, PTC congestion or proteinaceous casts in the cortex and medulla, similar to control-rat kidneys. (Magnifications: ×400 in A-H). CM: contrast media; PTC: peritubular capillaries; TEC: tubular epithelial cells.