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Figure 4 | BMC Complementary and Alternative Medicine

Figure 4

From: Antineuropathic effect of 7-hydroxy-3,4-dihydrocadalin in streptozotocin-induced diabetic rodents

Figure 4

Effect of systemic s.c. naltrexone (NTX, opioid antagonist, A-B), i.p. methiothepin (MET, 5-HT antagonist, C-D), and i.p. 1H-[1,2,4] oxadiazolo[4,3-a]quinoxalin-1-one (ODQ, guanylyl cyclase inhibitor, E-F) on p.o. 7-hydroxy-3,4-dihydrocadalin-induced (7-DHC) antihyperalgesic effect during both phases of 0.5% formalin test in diabetic rats (3 weeks). 7-DHC was given 1 h before formalin injection whereas antagonists or inhibitor were given 30 min after oral 7-DHC administration. Antagonists or inhibitor did not show any nociceptive effect by themselves at the tested dose for its administration with 7-DHC. Data are expressed in bars as average of the area under the curve (AUC) ± E.E.M. of six animals per group. *Significantly different (P < 0.05) from control group (diabetic) and #significantly different (P < 0.05) from 7-DHC group (30 mg/kg), as determined by one-way ANOVA followed by the Tukey’s test. AUC: Area under the curve; n.s.: not significant.

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