Figure 2

Liver photomicrographs. A) Vehicle control showed normal architecture of normal liver histology, central vein (CV), hepatocytes (H). B) Hepatotoxic liver after treatment with CCl₄ showing ere necrosis (N) of the hepatocytes in parenchyma region, as well as macrovesicular steatosis (S). C) Pre-treatment with 200 mg/kg of Silymarin, positive control preserves normal architecture of the hepatocytes. D) Pre-treatment with 50 mg/kg of MEDL showing mild necrosis with mild infiltration of inflammatory cell E) Pre-treatment with 250 mg/kg of MEDL showing mild macrovesicular steatosis and absent to few degree of hepatocyte necrosis. F) Pre-treatment with 500 mg/kg of MEDL showing macrovesicular steatosis around central vein region. H & E staining, 40 × magnifications.