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Table 1 Effect of dichloromethane crude extract of aerial parts of A. abyssinica on parasitaemia and mean survival time of T. congolense infected mice

From: Evaluation of in vivo antitrypanosomal activity of crude extracts of Artemisia abyssinica against aTrypanosoma congolense isolate

Treatment

Dose (mg/kg)

Parasitaemia level (log number)/ml

Mean survival time (days)

D0

D2

D4

D6

D8

D10

D12

D14

DCM ext

100

6.68 ± 0.23

7.08 ± 0.25

7.57 ± 0.26bc

7.83 ± 0.14bcd

6.31 ± 0.46cd

6.70 ± 1.37c

7.31 ± 0.44cd

6.41 ± 1.34c

34.33 ± 4.63

DCM ext

200

7.05 ± 0.18

7.04 ± 0.23

5.65 ± 1.18bc

3.80 ± 1.20a

3.92 ± 1.37a

6.70 ± 0.30c

6.78 ± 0.39c

7.07 ± 0.32c

37.83 ± 3.49

DCM ext

400

7.00 ± 0.30

6.95 ± 0.26

4.90 ± 0.98ac

2.80 ± 1.26a

1.95 ± 1.24a

3.70 ± 1.17a

4.85 ± 0.99abc

4.95 ± 1.01a

40.67 ± 2.42

DA

3.5

7.09 ± 0.06

1.25 ± 1.25

1.90 ± 1.20a

3.30 ± 1.48a

4.60 ± 1.48c

6.12 ± 1.26c

7.41 ± 0.40cd

7.92 ± 0.27c

36.83 ± 4.36

DA

28

7.13 ± 0.05

0.00 ± 0.00

0.00 ± 0.00a

0.00 ± 0.00a

0.00 ± 0.00ab

0.00 ± 0.00f

0.90 ± 0.90e

1.85 ± 1.17f

42.00 ± 0.00

Distilled water

1 ml

6.94 ± 0.26

7.97 ± 0.12

8.67 ± 0.10

8.54 ± 0.07

8.46 ± 0.17

8.70 ± 0.06

8.14 ± 0.27

8.45 ± 0.21

34.33 ± 6.15

  1. Values are mean ± SEM; n = 6; D = day; D0 = the day treatment commenced; SEM = standard error of mean; DCM = Dichloromethane; ext = extract; DA = Diminazene aceturate; All superscripts indicate significance at p < 0.05 (a = compared to negative control; b = compared to 3.5 mg/kg DA; c = compared to 28 mg/kg DA; d = compared to 400 mg/kg; e = compared to all groups, f = compared to all groups but 400 mg/kg).