Treatment | Dose (mg/kg) | Parasitaemia level (log number)/ml | Mean survival time (days) | |||||||
---|---|---|---|---|---|---|---|---|---|---|
D0 | D2 | D4 | D6 | D8 | D10 | D12 | D14 | |||
DCM ext | 100 | 6.68 ± 0.23 | 7.08 ± 0.25 | 7.57 ± 0.26bc | 7.83 ± 0.14bcd | 6.31 ± 0.46cd | 6.70 ± 1.37c | 7.31 ± 0.44cd | 6.41 ± 1.34c | 34.33 ± 4.63 |
DCM ext | 200 | 7.05 ± 0.18 | 7.04 ± 0.23 | 5.65 ± 1.18bc | 3.80 ± 1.20a | 3.92 ± 1.37a | 6.70 ± 0.30c | 6.78 ± 0.39c | 7.07 ± 0.32c | 37.83 ± 3.49 |
DCM ext | 400 | 7.00 ± 0.30 | 6.95 ± 0.26 | 4.90 ± 0.98ac | 2.80 ± 1.26a | 1.95 ± 1.24a | 3.70 ± 1.17a | 4.85 ± 0.99abc | 4.95 ± 1.01a | 40.67 ± 2.42 |
DA | 3.5 | 7.09 ± 0.06 | 1.25 ± 1.25 | 1.90 ± 1.20a | 3.30 ± 1.48a | 4.60 ± 1.48c | 6.12 ± 1.26c | 7.41 ± 0.40cd | 7.92 ± 0.27c | 36.83 ± 4.36 |
DA | 28 | 7.13 ± 0.05 | 0.00 ± 0.00 | 0.00 ± 0.00a | 0.00 ± 0.00a | 0.00 ± 0.00ab | 0.00 ± 0.00f | 0.90 ± 0.90e | 1.85 ± 1.17f | 42.00 ± 0.00 |
Distilled water | 1 ml | 6.94 ± 0.26 | 7.97 ± 0.12 | 8.67 ± 0.10 | 8.54 ± 0.07 | 8.46 ± 0.17 | 8.70 ± 0.06 | 8.14 ± 0.27 | 8.45 ± 0.21 | 34.33 ± 6.15 |