Antibacterial constituents of three Cameroonian medicinal plants: Garcinia nobilis, Oricia suaveolens and Balsamocitrus camerunensis

Table 1 MICs of the extracts, compounds from Garcinia nobilis, Oricia suaveolens , Balsmocitrus camerunensis and reference drugs on documented strains and clinical MDR isolates

Tested samples^a	Microorganisms, strains and MIC (μg/ml)^b
	E. coli			E. aerogenes			K. pneumoniae		P. stuartii		P. aeruginosa		M. tuberculosis
	ATCC 10536	AG 100	AG 102	ATCC 13048	CM 64	EA 27	ATCC 11296	KP55	ATCC 29916	NAE 16	PA 01	PA 124	ATCC 27294	MTCS1	MTCS2
Crude extracts
GNB	64	256	256	256	512	256	128	512	512	-	512	-	128	256	256
OSR	128	512	-	512	-	-	256	256	512	256	-	-	512	-	512
OSW	128	512	-	-	-	-	128	128	-	128	-	-	256	-	512
BCB	512	-	-	256	-	-	512	512	-	-	-	-	-	-	-
Compounds
1	256	128	-	-	-	-	-	-	-	-	-	-	-	-	-
2	64	64	128	128	256	64	512	512	256	64	64	128	8	32	8
3	128	128	64	256	-	256	-	-	-	-	-	-	64	-	128
4	-	64	128	-	256	128	-	-	-	-	256	-	512	-	512
5	64	128	128	-	-	512	512	-	512	-	64	128	32	64	64
8	512	128	256	-	512	128	512	-	-	-	-	-	128	512	256
9	-	128	256	-	256	256	-	-	-	-	-	-	-	-	-
10	64	128	256	-	-	128	-	-	512	-	-	-	128	-	512
11	128	256	128	-	256	512	512	-	-	-	-	512	-	-	-
13	512	64	256	-	512	128	256	-	-	-	128	512	256	512	512
15	128	256	256	-	-	256	-	-	-	-	-	-	-	-	-
16	128	128	-	-		512	-	-	512	-	-	-	512	-	-
17	-	128	-	-	-	-	-	-	-	-	-	-	-	-	-
18	-	256	-	-	-	256	-	-	-	256	-	-	-	-	-
19	-	256	-	-	-	-	-	-	-	-	-	-	-	-	-
20	-	512	-	-	-	-	-	-	-	-	-	-	-	-	-
21	512	256	-	-	-	256	256	-	-	-	-	-	-	-	-
22	512	256	256	512	128	-	-	512	-	-	-	-	-	-	-
RA	<4	16	512	64	-	64	4	32	-	64	128	128	1	128	4

^aTested samples [methanol-dichloromethane 1:1 extract of the stem bark of Garcinia nobilis (GNB), the wood (OSW)roots (OSR) of Oricia suaveolens, and stem bark of Balsmocitrus camerunensis (BCB); compounds isolated from the stem bark of Garcinia nobilis (1–5), Oricia suaveolens woods (6–11) and roots (12–17), and the stem back of Balsmocitrus camerunensis (18–22); caroxanthone (1), 4-prenyl-2-(3,7-dimethyl-2,6-octadienyl)-1,3,5,8-tetrahydroxyxanthone (2), smeathxanthone A (3), 8-hydroxycudraxanthone G (4), morusignin I (5), stigma-5-en-3-ol (6), 20(29)lupen-2-ol (7), evoxanthine (8), norevoxanthine (9), 1-hydoxy-2,3-dimethoxy-10-methylacridone (10), 1,3-dimethoxy-10-methylacridone (11), kokusaginine (13), 1-hydroxy-4-methoxy-10-methylacridone (15), syringaresinol (16), limonin (17), 1-hydroxy-3,6-dimethoxy-8-methylxanthone (18), xanthoxyletin (19), imperatorin (20), 6,8-dimethoxycoumarin (21), umbelliferone (22)]; RA: reference antibiotics were chloramphenicol for bacteria, isoniazid for M. tuberculosis; ^b(−): MIC > 512 μg/mL.

ISSN: 2662-7671