Skip to main content

Table 3 IC50 (μg/mL) values for the in vitro cytotoxic activity of plants crude extracts on five human cancer cell lines

From: In vitro anticancer screening of 24 locally used Nigerian medicinal plants

Species BT-549 BT-20 PC-3 SW-480 JURKAT
Allanblackia floribunda 14.7 ± 0.23 48.3 ± 2.90 29.4 ± 0.69 57.1 ± 1.16 Nd
Bidens pilosa 43.1 ± 6.09 53.7 ± 2.16* 47.7 ± 2.69* Nd 75.6 ± 1.06*
Bryophyllum pinnatum 48.2 ± 1.56 82.4 ± 0.17* 48.3 ± 1.05* Nd Nd
Byrsocarpus coccineus Bark 24.6 ± 0.99 52.9 ± 4.11* 43.7 ± 1.02* Nd 65.2 ± 0.87*
Leaves 18.6 ± 4.85 31.3 ± 0.53* 29.1 ± 0.64* Nd 43.4 ± 1.77*
Cajanus cajan 56.1 ± 10.09 56.8 ± 2.60 50.5 ± 0.76 52 ± 0.53 Nd
Daniellia oliveri 28.1 ± 0.56 153.1 ± 1.56 130.0 ± 0.45 147.0 ± 0.47 Nd
Erythrophleum suaveolens 0.55 ± 0.18 0.50 ± 0.03 1.30 ± 0.14 0.80 ± 0.11 0.20 ± 0.05
Hoslundia opposita 76.4 ± 7.89 56.1 ± 1.57 59.7 ± 8.11 Nd >200
Jatropa curcas L. 21.3 ± 0.38 33.4 ± 0.70 >200 >200 >200
Landolphia dulcis 16.3 ± 4.31 >200 >200 >200 Nd
Lannea nigritana 48.2 ± 3.52 Nd >200 Nd 53.5 ± 0.35*
Parkia biglobosa 100.0 ± 0.67 125.0 ± 2.21 56.1 ± 0.45 136.0 ± 0.81 Nd
Parkia filicoidea 149.0 ± 2.65 >200 94.3 ± 0.50 Nd Nd
Pterocarpus santalinoides 57.9 ± 0.35 >200 >200 >200 10.2 ± 0.25
Sida acuta 10.3 ± 0.21 41.1 ± 1.05 37.1 ± 0.18 Nd 42.3 ± 0.79
Tetrapleura tetraptera 9.1 ± 1.40 23.1 ± 7.05 Nd Nd 37.5 ± 5.13*
Vitex doniana Bark 62.5 ± 0.23 171.1 ± 1.33 >200 89.2 ± 6.65 84.0 ± 1.13
Root 44.9 ± 0.10 152.3 ± 1.22 177.3 ± 1.01 45.6 ± 1.35 43.4 ± 0.64
  1. Results are expressed as mean ± SD (μg/mL) of three replicate experiments. Nd = Not determined. There was a significant difference in cell inhibition in extract-treated cultures compared with DMSO-control in all cell lines (P<0.05).