Figure 1

Glycemia in diabetic pregnant rats treated with plant extracts on day12 (A), day16 (B) and day21 (C) of gestation. Pregnant rats were rendered diabetic by administration of five low doses of streptozotocin, starting on day5 of gestation. Lyophilised plant extracts diluted in sterile physiological saline solution (NaCl 0.9%) were sterilized and filtrated [filter 0.20 μm (Nalge Nunc International Corp., USA)] and injected intraperitoneally to diabetic or control animals from day12 to day15 of gestation (four days). Values are mean ± SEM. (§) p < 0.01 = significant difference between diabetic rats compared with treated/untreated control animals. (*) p < 0.01 = significant difference between plant/insulin-treated diabetic rats compared with untreated diabetic animals. NS = non-significant difference. A: Picra-EtOH: ethanolic fraction of Picralima nitida; B: Picra-But: butaniolic fraction of Picralima nitida; C: Nauclea-EtOH: ethanolic fraction of Nauclea latifolia; D: Nauclea-But: butanolic fraction of Nauclea latifolia; E: Oxy-EtOH: butanolic fraction of Oxytenanthera abyssinica.