Figure 2From: Regulation of podocalyxin expression in the kidney of streptozotocin-induced diabetic rats with Chinese herbs (Yishen capsule) Expression of podocalyxin in the kidney after STZ injection in rats. Kidney histology and expression of podocalyxin were documented with HE staining, immunofluorescent staining of podocalyxin and RT-PCR analysis of podocalyxin mRNA respectively. As shown in panel A, glomerulus was damaged and podocalyxin fluorescent intensity was reduced (magnification x400). The expression of podocalyxin was gradually reduced from 0 to 12 weeks after STZ injection. The expression of podocalyxin was further documented by RT-PCR analysis of podocalyxin mRNA as displayed in panel B. Podocalyxin level at 12 weeks after STZ injection was about one third of normal value. Data are expressed as mean ± SD from eight rats. * indicates p < 0.05 as compared to normal control group.Back to article page