Table 5 Fifty per cent inhibition concentrations (IC 50s ) of Euphorbia hirta and Rauvolfia vomitoria extracts on Onchocerca volvulus microfilariae
Extract/Drug | Time of mff exposure (hrs) | |||||
|---|---|---|---|---|---|---|
2 | 4 | 6 | 12 | 24 | 48 | |
IC 50s of Euphorbia hirta (μg/ml) | ||||||
Crude | 500 | 125 | 75 | 50 | 40 | <6.25 |
Hexane | >800 | 700 | 700 | 700 | 150 | 17.5 |
Chloroform | 400 | 150 | 140 | 50 | 20 | <6.25 |
Ethyl acetate | 100 | 37.5 | 21.9 | 12.5 | <6.25 | <6.25 |
Water | 400 | 150 | 90 | 25 | 18.8 | <6.25 |
IC 50s of Rauvolfia vomitoria (μg/ml) | ||||||
Crude | >800 | 400 | 350 | 300 | 300 | <6.25 |
Hexane | >800 | 700 | 600 | 450 | 200 | <6.25 |
Chloroform | 650 | 600 | 450 | 400 | 400 | <6.25 |
Ethyl acetate | 650 | 625 | 625 | 625 | 450 | 37.5 |
Water | >800 | >800 | 800 | 400 | 200 | <6.25 |
IC 50s of the reference drugs (μg/ml) | ||||||
DMSPN | 100 | 40.5 | 18.8 | 14.1 | 6.25 | <6.25 |
Mel B | 600 | 500 | 400 | 87.5 | <6.25 | <6.25 |