Table 1 Percentage (± SE) of motile Onchocerca volvulus microfilariae found in 6.25 μg/ml to 200 μg/ml of Euphorbia hirta and Rauvolfia vomitoria extracts at 2 and 4 hrs
Extract/drug | Extract concentration(μg/ml) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
6.25 (μg/ml) | 12.5 (μg/ml) | 25 (μg/ml) | 50 (μg/ml) | 100 (μg/ml) | 200 (μg/ml) | |||||||
2Â hrs | 4Â hrs | 2Â hrs | 4Â hrs | 2Â hrs | 4Â hrs | 2Â hrs | 4Â hrs | 2Â hrs | 4Â hrs | 2Â hrs | 4Â hrs | |
Euphorbia hirta | ||||||||||||
Crude | 100 | 100 | 100 | 97(±3) | 100 | 95(±5) | 100 | 90(±10) | 100 | 55(±29) | 73(±24) | 36(±32) |
Hexane | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
Chloroform | 100 | 100 | 100 | 97(±3) | 100 | 92(±8) | 100 | 69(±22) | 100 | 71(±22) | 100 | 32(±21) |
Ethyl acetate | 100 | 98(±2) | 98(±2) | 96(±2) | 64(±28) | 54(±27) | 55(±29) | 46(±23) | 54(±29) | 38(±28) | 35(±19) | 2(±2) |
Aqueous | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 96(±4) | 62(±25) | 94(±4) | 43(±28) |
Rauvolfia vomitoria | ||||||||||||
Crude | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 90(±10) |
Hexane | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
Chloroform | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 98(±2) |
Ethyl acetate | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
Aqueous | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
Reference drugs | ||||||||||||
DMSPN | 100 | 100 | 100 | 92(±8) | 97(±3) | 70(±20) | 67(±33) | 38(±27) | 49(±28) | 17(±12) | 44(±28) | 14(±8) |
Mel B | 100 | 100 | 100 | 100 | 100 | 99(±1) | 100 | 99(±1) | 100 | 99(±1) | 94(±6) | 81(±11) |