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Table 1 General characteristic of the included studies

From: Potential effectiveness of traditional Chinese medicine for cardiac syndrome X (CSX): a systematic review and meta-analysis

Studies Case Age Gender Co F CP Outcome AE CI Type of TI TI
Year* (T/C) (M/F) (d)
Sun 2007 [24] 64(34/30) 37~62 T:13/21C:11/19 56 0 y AF,TT U RT Chinese patent drug Shenwuguanxinning granules 15 g tid + RT
Ge 2011 [25] 39(19/20) 45~56 10/29 28 0 y A,AF,TTET-1 U RT Decoction Nourishing Qi and Blood Decoction 1 150 mL qd + RT
Peng 2011 [26] 46(23/23) 35~65 18/28 56 0 y A,AF,TT N RT Chinese patent drug Xinnaotong capsule 0.8 g bid + RT
Niu 2008 [27] 50(30/20) 35~65 21/29 28 0 y A,AF,ECG,TT,TCM N RT Chinese patent drug Xinxuean granules 15 g tid + RT
Gao 2005 [28] 63(33/30) 45~64 0/63 28 0 y A U RT Decoction Xiaoyao decoction2 150 mL bid
Xu 2011 [29] 30(15/15) 35~60 10/20 28 0 y A,AF,TT U RT Chinese patent drug Wenxin granules3 9 g, tid + RT
Bi 2003 [30] 60(30/30) 44~61 27/33 28 6 m y A N RT Chinese patent drug Tongxinluo 1.52 g, tid
Wang 2009 [31] 55(28/27) 43~65 T: 5/23 C: 3/24 14 0 y A,ECG,TCM,TTET-1,NOhs-CRP N RT Decoction Kuanxionghuoxue decoction4 150 ml bid + RT
Xu LJ 2002 [32] 56(36/20) 31~48 T:23/13 C:13/7 7 7d y A,ET-1,Holter U RT Chinese patent drug Quanshi capsule 1.5 g tid
Liu 2008 [33] 58(38/20) 36~55 37/21 U 0 y A,ECG U RT Chinese patent drug Naoxintong tablets, 1.6 g, tid
Zhang 2002 [34] 40(20/20) 30~59 18/22 15 0 y A,ECG U RT Decoction Taohongsiwu decoction5 150 mL qd
Lu 2007 [35] 114(72/72 18~60 56/88 84 0 y TT,ECG N RT Chinese patent drug Tongxinluo capsule 1.52 g tid
Zhu 2003 [36] 60(30/30) 30~59 38/22 15 0 y A,ECG U RT Decoction Xuefuzhuyu decoction 6150 mL qd
Liang 2005 [37] 42(21/21) 51~60 12/30 28 0 y A,AF, TCM,TT hs-CRP N RT placebo Chinese patent drug Danshen tablets, three tablets per time, tid + RT
Yuan 2008 [38] 40(20/20) 48~67 T:9/11 C:13/7 28 0 y AF,TT U RT Injection Danhong injection 30 ml + 5% glu or 0.9% NaCI 250 ml, iv, qd
Wang GF 2008 [39] 36(18/18) 33~70 T:3/15 C:2/16 28 0 y AF,TT,CRP,ET-1,NO N RT Decoction Guanmailing decoction7 150 ml bid+ RT
Zhang SL 2008 [40] 72(36/36) 37~62 T:6/30 C:3/31 20 0 y A N R Chinese patent drug Guanmaining 8 10 ml tid + xiaoyao pill, 8 pills, tid+ RT
Zhang XY 2008 [41] 68(48/28) 42~58 T:11/37 C:6/14 21 0 y A,ECG U RT Decoction Individualized Chinese formulas against different patterns of syndrome9 150 ML bid+ RT
Wu 2010 [42] 50(26/24) 39~50 T:10/16 C: 9/15 15 0 y AF,TT, CRP N RT Injection Shuxuening injection 20 ml+ 0.9% NaCI 250 ml, iv, qd+ RT
Li 2009 [43] 68(36/32) 49~64 T:16/20 C:14/18 30 0 y ECG, blood lipid, ET-1,No, Y RT Chinese patent drug Tongxinluo capsule, 2.14 g, tid + RT
Feng 2005 [44] 32(16/16) 37~51 T:7/9 C:8/8 28 0 y AF,TT ET-1 U RT Chinese patent drug Tongxinluo capsule, 1.14 g tid+ RT
  1. Table Legends :
  2. * Studies were marked by the surname of the first author followed by the year of publication . An abbreviation of the first name was appended if authors share the same surname.
  3. Abbreviation: Co(d)-medication course; F-follow-up; C-compatibility; Y-yes; U-unclear; N-no; RT-routine treatment; A-the symptom of angina; AF-angina frequency; TT-treadmill test; ECG-electrocardiogram; AE-adverse event; CI-intervention in the controlled group; TI- intervention in the treatment group; T- treatment group; C-controlled group, d-day; m-month.
  4. Herbal supplements in the decoction:
  5. 1 Nourishing Qi and Blood Decoction (huangqi 30 g, chaihu 12 g, gualoupi 15 g, xiebai 15 g, houpou 15 g, jiangbanxia 9 g, zhiqiao 9 g, huanglian 3 g, tanxiang 9 g, dansen 9 g, chuanxiong 9 g, danggui 6 g, baishao 12 g, baizhu 15 g, zhigancao 6 g, dangshen 12 g).
  6. 2 Xiaoyao decoction (chaihu 10 g, danggui 15 g, chishao15g, baishao 15 g, gancao 6 g, danshen 30 g, chuanxiong 10 g, honghua 10 g, sanqi 3 g, qianhu 10 g).
  7. 3 Wenxin granules (dangshen, huangjing, sanqi, hupo, gansong).
  8. 4 Kuanxionghuoxue decoction(chaihu 10 g, zhiqiao 12 g, guoloupi 15 g, xiebai 10 g, fuling 12 g, baizhu 12 g, chenpi12g, chuanxiong 10 g, danggui 12 g, danshen 15 g, yanhusuo 15 g, honghua 15 g).
  9. 5 Taohongsiwu decoction (taoren 10 g, honghua 10 g, danggui 15 g,danshen 30 g, sanqi powder 3 g, guoloupi 18 g, gegen 30 g, chuanxiong 10 g, guizhi 6 g).
  10. 6 Xuefuzhuyu decoction(danggui 15 g, taoren 15 g, honghua 15 g, chishao 15 g, chuanxiong 15 g, shengdihuang 15 g, niuxi 10 g, zhiqiao 10 g, chaihu 10 g, jiegeng 6 g).
  11. 7 Guanmailing formula(danshen 20 g, tanxiang 10 g, sharen 10 g, gualou 10 g, xiebai 10 g, zhiqiao 10 g, sanqi 10 g, chuanxiong 10 g, yinxingye 10 g, honghua 6 g, jiuxiangchong 10 g, 150 ml one pocket).
  12. 8 Guanmaiding (huangqi, sanleng, xiebai).
  13. 9 Individualized Chinese herbal formula against different patterns of syndrome.
  14. Basic formula: chaihu, zhiqiao, chishao, baishao, xiangfu, chuanxiong, fuling, chenpi, suanzaoren, danshen, yuanzhi, taoren, honghua, danggui and gancao.
  15. Adding huangqi, dangshen and baizhu for patients with Qi-deficiency; Adding anpi and zhizi for patients with excessive heat; Adding gualou, xiebai and baikouren for patients with phlegm.