TY - JOUR AU - Silveira, Jéssica PS AU - Seito, Leonardo N. AU - Eberlin, Samara AU - Dieamant, Gustavo C. AU - Nogueira, Cecília AU - Pereda, Maria CV AU - Di Stasi, Luiz C. PY - 2013 DA - 2013/02/27 TI - Photoprotective and antioxidant effects of Rhubarb: inhibitory action on tyrosinase and tyrosine kinase activities and TNF-α, IL-1α and α-MSH production in human melanocytes JO - BMC Complementary and Alternative Medicine SP - 49 VL - 13 IS - 1 AB - Exposure to ultraviolet (UV) radiation causes various forms of acute and chronic skin damage, including immunosuppression, inflammation, premature aging and photodamage. Furthermore, it induces the generation of reactive oxygen species, produces proinflammatory cytokines and melanocyte-stimulating hormone (MSH) and increases tyrosinase activity. The aim of this study was to evaluate the potential photoprotective effects of Rheum rhaponticum L. rhizome extract on human UV-stimulated melanocytes. SN - 1472-6882 UR - https://doi.org/10.1186/1472-6882-13-49 DO - 10.1186/1472-6882-13-49 ID - Silveira2013 ER -