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Table 4 Comparison of anti-protozoal activity (IC 50 ) and cytotoxicity (CC 50 ) of alkaloids from Annickia kummeriae with standard drugs

From: Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae)

Compound IC50cpd IC50CQ IC50cpd IC50Art IC50cpd IC50Mel IC50cpd IC50Milt CC50cpd CC50Pdx
Lysicamine (1) 38.1 1,200.0 1,850.0 23.6 177.8
Trivalvone (2) 25.4 800.0 7,150.0 26.4 5,033.3
Palmatine (3) 1.3 40.0 1,600.0 70.9 >10,000
Jatrorrhizine (4) 3.8 120 2,100.0 185.5 >10,000
Jatrorrhizine (4) + columbamine (5) (1.2:1.0) 2.2 69.0 2,000.0 119.1 5,577.8
Palmatine (3) + (−)- tetrahydropalmatine (6) (1.1:1.0) 1.6 49.0 2,150.0 63.64 6,855.6
  1. Cpd isolated compound, CQ chloroquine, Art artemisinin, Mel melarsoprol, Pdx podophyllotoxin.